Ebastine

Indications

Ebastine is used for: Allergic rhinitis, Allergic conditions, Chronic idiopathic urticaria

Adult Dose

Oral Allergic conditions Adult: 10-20 mg once daily.

Child Dose

Oral Allergic conditions Child: >6 yr: 5 mg once daily.

Renal Dose

Administration

May be taken with or without food.

Contra Indications

Hypersensitivity, cardiac arrhythmias.

Precautions

Caution is advised when used in hepatic impairment, renal insufficiency, QTc interval prolongation. Pregnancy, lactation.

Pregnancy-Lactation

Interactions

Concomitant use of ketoconazole, itraconazole, clarithromycin or erythromycin may increase plasma levels of ebastine and cause QTc interval prolongation.

Side Effects

Side effects of Ebastine : Headache, dry mouth, drowsiness, pharyngitis, abdominal pain, dyspepsia, asthenia, epistaxis, rhinitis, sinusitis, nausea, insomnia.

Mode of Action

Ebastine, a piperidine derivative, is a long-acting, nonsedating, second-generation histamine receptor antagonist that binds preferentially to peripheral H1 receptors. It is metabolised to active metabolite, carebastine. It has antihistaminic, antiallergic activity and prevents histamine-induced bronchoconstriction. It does not have significant sedative or antimuscarinic actions.