Indications
Notezine Tablet is used for:
Filariasis, Lymphatic filariasis, Pulmonary eosinophilia, Loiasis, Toxocariasis
Adult Dose
W. Bancrofti, B Malayi
Day 1: 50 mg PO PC
Day 2: 50 mg TID
Day 3: 100 mg TID
Day 4-14: 6 mg/kg/day divided TID
Loa Loa
Day 1: 50 mg PO PC
Day 2: 50 mg TID
Day 3: 100 mg TID
Day 4-21: 9 mg/kg/day divided TID
M. Streptocerca
6 mg/kg PO qDay x14 days
Pulmonary Eosinophilia, Tropical
Pulmonary eosinophilia, tropical: 6 mg/kg/day divided TID x14 days
Larva Migrans, Visceral
6 mg/kg/day divided TID x7-10 days
Child Dose
W. Bancrofti, B Malayi
Day 1: 1 mg/kg PO PC
Day 2: 1 mg/kg PO TID
Day 3: 1-2 mg/kg PO TID
Day 4-14: 6 mg/kg/day divided TID
Loa Loa
Day 1: 1 mg/kg PO PC
Day 2: 1 mg/kg PO TID
Day 3: 1-2 mg/kg PO TID
Day 4-21: 9 mg/kg/day divided TID
Pulmonary Eosinophilia, Tropical
Pulmonary eosinophilia, tropical: 6 mg/kg/day divided TID x14 days
Larva Migrans, Visceral
6 mg/kg/day divided TID x7-10 days
Renal Dose
Administration
Contra Indications
Pregnancy, hypersensitivity; lactation; infants, elderly or debilitated patients; impaired renal function; cardiac disease.
Precautions
Patients with poor health.
Lactation: not known if excreted in breast milk
Pregnancy-Lactation
Pregnancy Category: X
Lactation: not known if excreted in breast milk
Interactions
Side Effects
Side effects of Diethylcarbamazine Citrate :
Fever, headache, vomiting, dizziness, drowsiness, nausea, chills.
Potentially Fatal: Severe hypersensitivity reactions may occur especially in the treatment of onchocerciasis where rare Mazzotti reaction characterised by rash, itching, headache, muscle and joint pains, tachycardia, postural hypotension may start within 2 hr of drug administration. Encephalitis and retinal haemorrhage.
Mode of Action
Diethylcarbamazine is an anthelmintic that is used in the treatment of lymphatic filariasis. It is active against the microfilariae and adult worms of W. bancrofti, B. malayi, B. timori and Loa loa but only against the microfilariae of O. volvulus. It is also used in treatment of toxocariasis. Repeated courses may be necessary.
Note
Notezine 50 mg Tablet generic name is Diethylcarbamazine Citrate. Notezine 50 mg Tablet is manufactured by Synovia Pharma PLC.Notezine is availble in all over Bangladesh.
Mes BD drug index information on Notezine Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.