Mizol Oral Gel

Miconazole 2% Oral Gel
Medicon Pharmaceuticals Ltd.
Pack size 15 gm tube
Unite Price 56.81 BDT

Indications

Mizol Oral Gel is used for: Oropharyngeal candidiasis, Oral thrush, Denture stomatitis, Fungal infections of the mouth, Throat and gut, Angular cheilitis, Dermatomycoses, Tinea pedis, Tinea corporis, Tinea cruris, Tinea versicolor

Adult Dose

Mouth/Throat Oropharyngeal candidiasis, Intestinal candidiasis Adult: The usual dose is 15 mg/kg/day in divided doses. One or two tea spoonfuls (5-10 ml) of gel four times daily. Continue treatment for at least 1 wk after symptoms have disappeared. Localised lesions of mouth: Smear small amount on affected area with clean finger 4 times daily for 5-7 days.

Child Dose

Mouth/Throat Oropharyngeal candidiasis Children aged 6 years and over: One tea-spoonful (5 ml) of gel four times daily. Children aged 2-6 years: One tea-spoonful (5 ml) of gel twice daily. Infants under 2 years: Half tea-spoonful (2.5 ml) of gel twice daily. Continue treatment for at least 1 wk after symptoms have disappeared. Localised lesions of mouth: Smear small amount on affected area with clean finger 4 times daily for 5-7 days.

Renal Dose

Administration

Apply on oral lesions and retain in the mouth as long as possible before swallowing. For localised lesions of the mouth, a small amount of gel may be applied directly to the affected area with a clean finger.

Contra Indications

Miconazole Oral Gel is contraindicated in patients with known hypersensitivity to any of its components and in patients with liver dysfunction.

Precautions

Caution is required particularly in infants & young children to ensure that the gel does not obstruct the throat. Lactation: Unknown whether distributed in breast milk, caution advised

Pregnancy-Lactation

Interactions

May increase anticoagulant effect of warfarin. May increase or prolong the effect of the following drugs: Oral hypoglycaemics (e.g. sulfonylureas), phenytoin, HIV protease inhibitors (e.g. saquinavir), antineoplastic agents (e.g. vinca alkaloids, busulfan, docetaxel), Ca channel blockers (e.g. dihydropyridines, verapamil), immunosuppressive agents (e.g. ciclosporin, tacrolimus, sirolimus), carbamazepine, cilostazol, buspirone, disopyramide, alfentanil, sildenafil, alprazolam, brotizolam, midazolam IV, rifabutin, methylprednisolone, trimetrexate, ebastine and reboxetine. Potentially Fatal: Increased risk of cardiac arrhythmia w/ astemizole, cisapride, dofetilide, halofantrine, mizolastine, pimozide, quinidine, sertindole, terfenadine. May increase exposure to ergot alkaloids leading to ergotism. May increase the risk of rhabdomyolysis w/ HMG-CoA reductase inhibitors (e.g. simvastatin and lovastatin). May increase the effect of triazolam and oral midazolam.

Side Effects

Side effects of Miconazole 2% Oral Gel : 1-10% Diarrhea (6%), Nausea (4.6%), Headache (5%), Dysgeusia (2.9%), Upper abdominal pain (2.5%), Vomiting (2.5%)

Mode of Action

Miconazole inhibits ergosterol synthesis thus damaging fungal cell wall membrane and increases its permeability, allowing leakage of nutrients.

Note

Mizol Oral Gel generic name is Miconazole 2% Oral Gel. Mizol Oral Gel is manufactured by Medicon Pharmaceuticals Ltd.Mizol is availble in all over Bangladesh. Mes BD drug index information on Mizol Oral Gel is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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