Dakrin Oral Gel
Miconazole 2% Oral Gel
General Pharmaceuticals Ltd.
| Pack size | 15 gm tube |
|---|---|
| Unite Price | 60.18 BDT |
Indications
Dakrin Oral Gel is used for:
Oropharyngeal candidiasis, Oral thrush, Denture stomatitis, Fungal infections of the mouth, Throat and gut, Angular cheilitis, Dermatomycoses, Tinea pedis, Tinea corporis, Tinea cruris, Tinea versicolor
Adult Dose
Mouth/Throat
Oropharyngeal candidiasis, Intestinal candidiasis
Adult: The usual dose is 15 mg/kg/day in divided doses.
One or two tea spoonfuls (5-10 ml) of gel four times daily.
Continue treatment for at least 1 wk after symptoms have disappeared.
Localised lesions of mouth: Smear small amount on affected area with clean finger 4 times daily for 5-7 days.
Child Dose
Mouth/Throat
Oropharyngeal candidiasis
Children aged 6 years and over: One tea-spoonful (5 ml) of gel four times daily.
Children aged 2-6 years: One tea-spoonful (5 ml) of gel twice daily.
Infants under 2 years: Half tea-spoonful (2.5 ml) of gel twice daily.
Continue treatment for at least 1 wk after symptoms have disappeared.
Localised lesions of mouth: Smear small amount on affected area with clean finger 4 times daily for 5-7 days.
Renal Dose
Administration
Apply on oral lesions and retain in the mouth as long as possible before swallowing. For localised lesions of the mouth, a small amount of gel may be applied directly to the affected area with a clean finger.
Contra Indications
Miconazole Oral Gel is contraindicated in patients with known hypersensitivity to any of its components and in patients with liver dysfunction.
Precautions
Caution is required particularly in infants & young children to ensure that the gel does not obstruct the throat.
Lactation: Unknown whether distributed in breast milk, caution advised
Pregnancy-Lactation
Interactions
May increase anticoagulant effect of warfarin. May increase or prolong the effect of the following drugs: Oral hypoglycaemics (e.g. sulfonylureas), phenytoin, HIV protease inhibitors (e.g. saquinavir), antineoplastic agents (e.g. vinca alkaloids, busulfan, docetaxel), Ca channel blockers (e.g. dihydropyridines, verapamil), immunosuppressive agents (e.g. ciclosporin, tacrolimus, sirolimus), carbamazepine, cilostazol, buspirone, disopyramide, alfentanil, sildenafil, alprazolam, brotizolam, midazolam IV, rifabutin, methylprednisolone, trimetrexate, ebastine and reboxetine.
Potentially Fatal: Increased risk of cardiac arrhythmia w/ astemizole, cisapride, dofetilide, halofantrine, mizolastine, pimozide, quinidine, sertindole, terfenadine. May increase exposure to ergot alkaloids leading to ergotism. May increase the risk of rhabdomyolysis w/ HMG-CoA reductase inhibitors (e.g. simvastatin and lovastatin). May increase the effect of triazolam and oral midazolam.
Side Effects
Side effects of Miconazole 2% Oral Gel :
1-10%
Diarrhea (6%), Nausea (4.6%), Headache (5%), Dysgeusia (2.9%), Upper abdominal pain (2.5%), Vomiting (2.5%)
Mode of Action
Miconazole inhibits ergosterol synthesis thus damaging fungal cell wall membrane and increases its permeability, allowing leakage of nutrients.
Note
Dakrin Oral Gel generic name is Miconazole 2% Oral Gel. Dakrin Oral Gel is manufactured by General Pharmaceuticals Ltd.Dakrin is availble in all over Bangladesh.
Mes BD drug index information on Dakrin Oral Gel is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.