Indications
Mercazole Tablet is used for:
Grave's disease, Hyperthyroidism, Diabetic nephropathy, Preparation for thyroidectomy
Adult Dose
Oral
Hyperthyroidism, Adjunct to radio-iodine therapy, Grave's disease, Preparation for thyroidectomy
Adult: Initially, 20-60 mg daily as a single or divided dose, reduced gradually once euthyroidism is achieved. Maintenance: 5-15 mg daily for at least 1 yr or 18 mth.
Hepatic impairment: Severe: Contraindicated.
Child Dose
Oral
Hyperthyroidism; Adjunct to radio-iodine therapy; Preparation for thyroidectomy
Child: 3-17 yr Initially, 15 mg daily, adjusted according to response.
Renal Dose
Administration
May be taken with or without food. Take consistently w/ or w/o meals.
Contra Indications
Hyperthyroidism due to nodular goitre.
Precautions
Liver diseases, pregnancy, lactation.
Pregnancy-Lactation
Interactions
Increased serum levels of theophylline or may develop toxicity. May enhance the effect of anticoagulants.
Potentially Fatal: Increased sensitivity to warfarin in hyperthyroidism and careful control required as patient is rendered euthyroid.
Side Effects
Side effects of Carbimazole :
Mild leucopaenia, sore throat, mouth ulcers, fever, bruising, malaise; rarely cholestatic jaundice; nephrotic syndrome. Nausea, loss of taste, headache, arthralgia, alopoecia.
Potentially Fatal: Agranulocytosis, aplastic anaemia, hypoprothrombinaemia, neutropaenia; hypothyroidism and goitre.
Mode of Action
Carbimazole is metabolised to methimazole which is responsible for its antithyroid action. It blocks the production of thyroid hormones by inhibiting thyroid peroxidase.
Note
Mercazole 5mg Tablet generic name is Carbimazole. Mercazole 5mg Tablet is manufactured by Renata LimitedMercazole is availble in all over Bangladesh.
Mes BD drug index information on Mercazole Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.