Liptor EZ 20 Tablet

Atorvastatin + Ezetimibe

20mg + 10mg

Acme Laboratories Ltd.

Pack size	30's Pack
Unite Price	24.00 BDT

Indications

Liptor EZ 20 Tablet is used for: Hypercholesterolaemia, Primary Hyperlipidemia

Adult Dose

Oral Hypercholesterolaemia Adult: Per tablet contains atorvastatin 10 mg and ezetimibe 10 mg: Usual starting: 1 tablet once daily.

Child Dose

Safety and efficacy not established

Renal Dose

Administration

May be taken with or without food.

Contra Indications

Hypersensitivity; active liver disease or unexplained persistent elevated liver function tests. Pregnancy and lactation.

Precautions

Hepatic impairment; patients consuming substantial quantities of alcohol with a history of liver disease. Not recommended for use in children <10 yr. Lactation: Because of the potential for adverse reactions in nursing infants, women taking this drug should not breast feed. Contraindicated in breastfeeding women.

Pregnancy-Lactation

Pregnancy Category: X Lactation: Because of the potential for adverse reactions in nursing infants, women taking this drug should not breast feed. Contraindicated in breastfeeding women.

Interactions

Atorvastatin: Increases digoxin levels; increases anticoagulant effect of warfarin. Avoid the combination of HMG-CoA reductase inhibitors and fibrates. Ezetimibe: Cholestyramine decreases AUC of ezetimibe by approx 55%; ciclosporin may increase ezetimibe levels. Potentially Fatal: Antacids decrease atorvastatin levels; colestipol decreases atorvastatin plasma levels; propranolol decreases antihyperlipidaemic activity of atorvastatin.

Side Effects

Side effects of Atorvastatin + Ezetimibe : 1-10% Increased ALT (5%), Increased AST (4%), Musculoskeletal pain (4%), Abdominal pain (3%), Nausea (3%), Arthralgias (3%), Muscle weakness (2%), Dizziness (2%), Hyperkalemia (2%), Hot flushes (2%), Coughing (2%), Bronchitis (2%), Sinusitis (2%)

Mode of Action

Atorvastatin competitively inhibits HMG-CoA reductase, the enzyme that catalyses the conversion of HMG-CoA to mevalonate which is an early rate-limiting step in cholesterol biosynthesis. Ezetimibe inhibits the absorption of cholesterol from the intestine, thus decreasing the delivery of intestinal cholesterol to the liver.

Note

Liptor EZ 20 20mg + 10mg Tablet generic name is Atorvastatin + Ezetimibe. Liptor EZ 20 20mg + 10mg Tablet is manufactured by Acme Laboratories Ltd.Liptor EZ 20 is availble in all over Bangladesh. Mes BD drug index information on Liptor EZ 20 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Atorvastatin + Ezetimibe :

Tablet

Atova EZ 10/10 ^{10 mg + 10 mg}

Beximco Pharmaceuticals Ltd.

Tablet

Atova EZ 20/10 ^{20mg + 10mg}

Beximco Pharmaceuticals Ltd.

Tablet

Liptor EZ 10 ^{10mg + 10mg}

Acme Laboratories Ltd.

Tablet

Ezitor 10/10 ^{10mg + 10mg}

Navana Pharmaceuticals Ltd.

Tablet

Ezitor 10/20 ^{20mg + 10mg}

Navana Pharmaceuticals Ltd.