Atova EZ Tablet
Atorvastatin + Ezetimibe
10 mg + 10 mg
Beximco Pharmaceuticals Ltd.
| Pack size | 30's Pack |
|---|---|
| Unite Price | 14.00 BDT |
Indications
Atova EZ Tablet is used for:
Hypercholesterolaemia, Primary Hyperlipidemia
Adult Dose
Oral
Hypercholesterolaemia
Adult: Per tablet contains atorvastatin 10 mg and ezetimibe 10 mg: Usual starting: 1 tablet once daily.
Child Dose
Safety and efficacy not established
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity; active liver disease or unexplained persistent elevated liver function tests. Pregnancy and lactation.
Precautions
Hepatic impairment; patients consuming substantial quantities of alcohol with a history of liver disease. Not recommended for use in children <10 yr.
Lactation: Because of the potential for adverse reactions in nursing infants, women taking this drug should not breast feed. Contraindicated in breastfeeding women.
Pregnancy-Lactation
Pregnancy Category: X
Lactation: Because of the potential for adverse reactions in nursing infants, women taking this drug should not breast feed. Contraindicated in breastfeeding women.
Interactions
Atorvastatin: Increases digoxin levels; increases anticoagulant effect of warfarin. Avoid the combination of HMG-CoA reductase inhibitors and fibrates. Ezetimibe: Cholestyramine decreases AUC of ezetimibe by approx 55%; ciclosporin may increase ezetimibe levels.
Potentially Fatal: Antacids decrease atorvastatin levels; colestipol decreases atorvastatin plasma levels; propranolol decreases antihyperlipidaemic activity of atorvastatin.
Side Effects
Side effects of Atorvastatin + Ezetimibe :
1-10%
Increased ALT (5%), Increased AST (4%), Musculoskeletal pain (4%), Abdominal pain (3%), Nausea (3%), Arthralgias (3%), Muscle weakness (2%), Dizziness (2%), Hyperkalemia (2%), Hot flushes (2%), Coughing (2%), Bronchitis (2%), Sinusitis (2%)
Mode of Action
Atorvastatin competitively inhibits HMG-CoA reductase, the enzyme that catalyses the conversion of HMG-CoA to mevalonate which is an early rate-limiting step in cholesterol biosynthesis. Ezetimibe inhibits the absorption of cholesterol from the intestine, thus decreasing the delivery of intestinal cholesterol to the liver.
Note
Atova EZ 10 mg + 10 mg Tablet generic name is Atorvastatin + Ezetimibe. Atova EZ 10 mg + 10 mg Tablet is manufactured by Beximco Pharmaceuticals Ltd.Atova EZ is availble in all over Bangladesh.
Mes BD drug index information on Atova EZ Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.