Indications
l-Cardin Tablet is used for:
Hypertension, Storke prevention
Adult Dose
Oral
Hypertension
Adult: Initially, 2 mg once daily, may increase after 3-4 wk to 4 mg/day. Max: 6 mg/day.
Hepatic impairment: Severe: Reduce dose.
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Within 1 mth of MI, cardiogenic shock, unstable angina, aortic stenosis.
Precautions
Conduction abnormalities, congenital or acquired QT prolongation, poor cardiac reserve. Hepatic impairment. Pregnancy and lactation.
Pregnancy-Lactation
Interactions
Additive effect w/ diuretics, ACE inhibitors and beta-blockers. May increase plasma level w/ cimetidine. Metabolism may be affected by CYP3A4 inhibitors (e.g. itraconazole) and inducers (e.g. rifampicin). May attenuate antihypertensive effect w/ corticoids or tetracosactid
Side Effects
Side effects of Lacidipine :
Headache, flushing, oedema, dizziness, palpitations, aggravation of angina, increased alkaline phosphatase. Rarely asthenia, rash (e.g. erythema and itching), gastric upset, nausea, gum hyperplasia, polyuria, muscle cramps, mood disturbances.
Mode of Action
Lacidipine is a potent dihydropyridine Ca antagonist mainly selective for Ca channels in the vascular smooth muscle. It dilates peripheral arterioles resulting in reduced peripheral vascular resistance and BP.
Note
l-Cardin 4mg Tablet generic name is Lacidipine. l-Cardin 4mg Tablet is manufactured by Drug International Ltd.l-Cardin is availble in all over Bangladesh.
Mes BD drug index information on l-Cardin Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.