Hepaclin Injection

L-Ornithine + L-Aspartate

5 gm/ 10 ml

Incepta Pharmaceuticals Ltd.

Pack size	1's
Unite Price	150.00 BDT

Indications

Hepaclin Injection is used for: Acute Hepatitis (Viral, non-viral, drug induced), Chronic Hepatitis (with or without hyperammonaemia), Cirrhosis of Liver, Fatty Liver with hyperammonaemia, Hepatic Encephalopathy, As an adjuvant therapy with all hepatotoxic drugs

Adult Dose

Injection (Infusion Concentrate) The recommended dose is up to 20 g (4 ampoules daily). In case of loss of consciousness (pre-coma) and clouding of consciousness (coma) up to 8 ampoule within 24 hours,depending on the severity of the condition. Oral 1-2 sachets is dissolved in a large amount of fluid (e.g. in a glass of water or juice) and is taken orally 3 times a day.

Child Dose

Renal Dose

Administration

Infusion concentrate 1) Infusion concentrate can be added to any of the conventional intravenous fluids (0.9% sodium chloride, 5% dextrose and Ringer's lactate etc.) 2) The normal dilution rate is 1 ampoule per 100ml of I.V. fluid. However, the dose should not exceed 6 ampoules per 500 ml. infusion. The solution mixtures were stable up to 24 hours. 3) Infusion Rate: 5 g/h at maximum. Oral Should be taken during or after meal.

Contra Indications

Patients with severe renal insufficiency.

Precautions

Caution needed for pregnant and breastfeeding women.

Pregnancy-Lactation

Interactions

Side Effects

Side effects of L-Ornithine + L-Aspartate : Increased wt; depressed mood, sleep disorder, nervousness, loss of libido, altered mood; headache, migraine; nausea, abdominal pain or distension, flatulence, vomiting; diarrhea, acne; alopecia; back pain; breast discomfort, ovarian cyst, hot flush, uterine/vaginal bleeding including spotting; asthenic conditions, irritability etc.

Mode of Action

Endogenous Amino Acids, L-Ornithine and L-Aspartate. After administration, it quickly breaks down into L-Ornithine and L-Aspartate. L-Ornithine being a substrate of urea cycle, converts toxic ammonia into non-toxic urea which is eliminated via kidneys, helping the diseased liver to carry out its normal function smoothly (detoxification). The process lowers the elevated level of ammonia in blood (hyperammonaemia) which is a common problem in most of the liver diseases. L-Aspartate is an essential component of citric acid cycle which liberates energy (ATP), and thus helps in regeneration of damaged liver cells.

Note

Hepaclin 5 gm/ 10 ml Injection generic name is L-Ornithine + L-Aspartate. Hepaclin 5 gm/ 10 ml Injection is manufactured by Incepta Pharmaceuticals Ltd.Hepaclin is availble in all over Bangladesh. Mes BD drug index information on Hepaclin Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of L-Ornithine + L-Aspartate :

Granules For Suspension

Hepagurd

Beximco Pharmaceuticals Ltd.

Granules For Suspension

Lola ^3gm

Jenphar Bangladesh Ltd.

Granules for Solution

Hepaclin ^3gm

Incepta Pharmaceuticals Ltd.

Tablet

Heplol 150 ^150mg

Square Pharmaceuticals Ltd.

Tablet

HepaMerz ^{150 mg + 100 mg}

Mundipharma (Bangladesh) Pvt. Ltd.