Combicid T/Cream
Clobetasol + Ofloxacin + Ornidazole + Terbinafine topical
15mg
Square Pharmaceuticals Ltd.
| Pack size | 1's Pack |
|---|---|
| Unite Price | 150.00 BDT |
Indications
Combicid T/Cream is used for:
Used in the treatment of, skin infections, Corticosteroid-responsive Dermatoses
Adult Dose
Adult
Topical
Corticosteroid-responsive Dermatoses
Cream: Apply thin layer to affected areas q12hr and rub in gently and completely
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity
Precautions
Should not be used on the face. Do not use the medication for longer periods of time.
It contains clobetasol which when used in higher doses and for longer periods can cause a change in the skin color, at the site of the application. Veins beneath the skin become visible because of thinning and weakening of the skin. There could be an increased hair growth. The medicine may get absorbed into the blood and can cause weight gain, high blood pressure and rounding of the face.
Pregnancy-Lactation
Interactions
Side Effects
Side effects of Clobetasol + Ofloxacin + Ornidazole + Terbinafine topical :
Application site reactions (burning, irritation, itching and redness), Thinning of skin, Skin peeling
Mode of Action
This is a combination of four medicines: Terbinafine, Clobetasol, Ofloxacin and Ornidazole, which treats skin infections.
Terbinafine is a allylamine derivative that has a wide spectrum of antifungal activity against pathogens of the skin, hair, and nails. It acts by inhibiting squalene epoxidase, the main enzyme responsible for fungal sterol synthesis. Thus, resulting to ergosterol deficiency, leading to membrane disruption and cell death. It is active against dermatophytes, moulds, and certain dimorphic fungi.
Clobetasol is a very potent corticosteroid used in short-term treatment of various inflammatory skin conditions. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation.
Ofloxacin is a fluoroquinolone which inhibits bacterial topoisomerase IV and DNA gyrase enzymes required for DNA replication, transcription, repair, transposition and recombination. It has antibacterial activity against a wide range of gm-ve and gm-+ve microorganisms.
Ornidazole is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria. It is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.
Note
Combicid 15mg T/Cream generic name is Clobetasol + Ofloxacin + Ornidazole + Terbinafine topical. Combicid 15mg T/Cream is manufactured by Square Pharmaceuticals Ltd.Combicid is availble in all over Bangladesh.
Mes BD drug index information on Combicid T/Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.