Alodia Tablet

Alogliptin
12.5 mg
Acme Laboratories Ltd.
Pack size 30's Pack
Unite Price 12.00 BDT

Indications

Alodia Tablet is used for: Type 2 diabetes mellitus

Adult Dose

Oral Type 2 diabetes mellitus Adult: 25 mg once daily. Hepatic impairment Mild-to-moderate (Child-Pugh A and B): No dosage adjustment required Severe (Child-Pugh C): Not studied

Child Dose

Renal Dose

Renal impairment Mild (CrCl >60mL/min): No dosage adjustment required Moderate (CrCl ?30 to <60 mL/min): Decrease dose to 12.5 mg PO qDay Severe (CrCl ?15 to <30 mL/min) or ESRD (CrCl <15 mL/min) or requiring hemodialysis: 6.25 mg PO qDay May administer without regard to the timing of dialysis Peritoneal dialysis: Not studied

Administration

May be taken with or without food.

Contra Indications

Type 1 diabetes mellitus or diabetic ketoacidosis. Hypersensitivity to alogliptin, including anaphylaxis, angioedema, or severe cutaneous adverse reactions including Stevens-Johnson syndrome

Precautions

Patient with abnormal LFT, history of pancreatitis, moderate to severe heart failure. Hepatic and moderate to severe renal impairment. DPP-4 inhibitors may cause disabling joint arthralgia. Pregnancy and lactation.

Pregnancy-Lactation

Pregnancy Category: B Lactation: Unknown whether distributed in breast milk

Interactions

Increased risk of hypoglycaemia with sulfonylurea (e.g. metformin), thiazolidinedione (e.g. pioglitazone) and insulin.

Side Effects

Side effects of Alogliptin : >10% Hypoglycemia (1.5-35%); higher when added to insulin 1-10% Nasopharyngitis (4.4%) Headache (4.2%) Upper respiratory tract infection (4.2%) <1% Hypersensitivity (0.6%) Pancreatitis (0.2%)

Mode of Action

Alogliptin inhibits dipeptidylpeptidase-4 (DPP-4), an enzyme that inactivates incretin hormones. Inhibition of DPP-4 result in an increase in the levels of hormones [e.g. GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotrophic polypeptide)] which regulate glucose homeostasis by increasing insulin synthesis and release from pancreatic β-cells and decreasing glucagon secretion from the pancreatic α-cells, leading to reduced hepatic glucose production.

Note

Alodia 12.5 mg Tablet generic name is Alogliptin. Alodia 12.5 mg Tablet is manufactured by Acme Laboratories Ltd.Alodia is availble in all over Bangladesh. Mes BD drug index information on Alodia Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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