Aloglip Tablet
Alogliptin
25mg
Navana Pharmaceuticals Ltd.
| Pack size | 30's Pack |
|---|---|
| Unite Price | 20.00 BDT |
Indications
Aloglip Tablet is used for:
Type 2 diabetes mellitus
Adult Dose
Oral
Type 2 diabetes mellitus
Adult:
25 mg once daily.
Hepatic impairment
Mild-to-moderate (Child-Pugh A and B): No dosage adjustment required
Severe (Child-Pugh C): Not studied
Child Dose
Renal Dose
Renal impairment
Mild (CrCl >60mL/min): No dosage adjustment required
Moderate (CrCl ?30 to <60 mL/min): Decrease dose to 12.5 mg PO qDay
Severe (CrCl ?15 to <30 mL/min) or ESRD (CrCl <15 mL/min) or requiring hemodialysis: 6.25 mg PO qDay
May administer without regard to the timing of dialysis
Peritoneal dialysis: Not studied
Administration
May be taken with or without food.
Contra Indications
Type 1 diabetes mellitus or diabetic ketoacidosis.
Hypersensitivity to alogliptin, including anaphylaxis, angioedema, or severe cutaneous adverse reactions including Stevens-Johnson syndrome
Precautions
Patient with abnormal LFT, history of pancreatitis, moderate to severe heart failure. Hepatic and moderate to severe renal impairment.
DPP-4 inhibitors may cause disabling joint arthralgia. Pregnancy and lactation.
Pregnancy-Lactation
Pregnancy Category: B
Lactation: Unknown whether distributed in breast milk
Interactions
Increased risk of hypoglycaemia with sulfonylurea (e.g. metformin), thiazolidinedione (e.g. pioglitazone) and insulin.
Side Effects
Side effects of Alogliptin :
>10%
Hypoglycemia (1.5-35%); higher when added to insulin
1-10%
Nasopharyngitis (4.4%)
Headache (4.2%)
Upper respiratory tract infection (4.2%)
<1%
Hypersensitivity (0.6%)
Pancreatitis (0.2%)
Mode of Action
Alogliptin inhibits dipeptidylpeptidase-4 (DPP-4), an enzyme that inactivates incretin hormones. Inhibition of DPP-4 result in an increase in the levels of hormones [e.g. GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotrophic polypeptide)] which regulate glucose homeostasis by increasing insulin synthesis and release from pancreatic β-cells and decreasing glucagon secretion from the pancreatic α-cells, leading to reduced hepatic glucose production.
Note
Aloglip 25mg Tablet generic name is Alogliptin. Aloglip 25mg Tablet is manufactured by Navana Pharmaceuticals Ltd.Aloglip is availble in all over Bangladesh.
Mes BD drug index information on Aloglip Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.