Yellow fever Virus (Live attenuated) Vaccine

Indications

Yellow fever Virus (Live attenuated) Vaccine is used for: Prophylaxis of Yellow fever infection

Adult Dose

Subcutaneous Active immunisation against yellow fever Adult: Primary Vaccination: 0.5 ml, given as SC inj (preferably into the deltoid area) as a single dose, at least 10 days prior to travel. Booster dose: Repeat dose every 10 yr for those at continued risk of exposure.

Child Dose

Child: >9 mth: 0.5 ml, given as SC inj (preferably into the deltoid area for children >3 yr and thigh area for children <3 yr), at least 10 days prior to travel. For booster dose: Repeat dose every 10 yr for those at continued risk of exposure.

Renal Dose

Administration

Contra Indications

Hypersensitivity reaction to eggs, chicken proteins or to any component of this vaccine. Serious hypersensitivity reactions (eg, anaphylaxis) after a previous dose of any yellow fever vaccine. Immunosuppression, whether congenital, idiopathic or as a result of treatment with systemic steroids (greater than the standard dose of topical or inhaled steroids), radiotherapy or cytotoxic drugs. History of thymus dysfunction (including thymoma, thymectomy). Symptomatic HIV infection. Asymptomatic HIV infection when accompanied by evidence of impaired immune function (see Precautions). Age <6 months (see Dosage & Administration and Precautions). Current severe febrile illness.

Precautions

Caution when used in immunocompromised patients e.g. patients receiving chemo/radiation therapy or other immunosuppressive therapy such as high-dose corticosteroids and patients <24 mth after haematopoietic stem cell transplant. Elderly; increased risk of adverse effects when used in patients ≥65 yr. Monitor for adverse events 10-30 days post-vaccination. Pregnancy. Lactation: There is a theoretical risk of transmission of vaccine components to the infants from breast-feeding mothers, lactation constitutes a contraindication, particularly when infants are <9 months of age because of the risk of encephalitis

Pregnancy-Lactation

Pregnancy Category: C Lactation: There is a theoretical risk of transmission of vaccine components to the infants from breast-feeding mothers, lactation constitutes a contraindication, particularly when infants are <9 months of age because of the risk of encephalitis

Interactions

Immunosuppressants eg cytotoxic agents, systemic steroids.

Side Effects

Side effects of Yellow fever Virus (Live attenuated) Vaccine : 1-10% Headache (5-10%), Chills (5-10%), Low-grade fever (5-10%), Myalgia (5-10%) Frequency Not Defined Meningoencephalitis, Seizures, Rash, Urticaria, Pain, Warmth, Erythema, Guillain-Barre syndrome

Mode of Action

Live, attenuated virus stimulates active immunity to Yellow fever; conveys active immunity via stimulation of production of endogenously produced antibodies.