Terconazole 0.4% Vag prep
Indications
Terconazole 0.4% Vag prep is used for:
Vulvovaginal candidiasis
Adult Dose
Vaginal
Vulvovaginal candidiasis
Adult: As cream: Apply intravaginally at bedtime for 7 consecutive days or for 3 consecutive days, respectively.
As 80 mg supp: Admin intravaginally at bedtime for 3 consecutive days.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity. Lactation.
Precautions
Discontinue if irritation or flu-like symptoms develop. May damage latex or rubber contraceptives. Patients <18 yrs. Pregnancy.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: unknown
Interactions
May decrease absorption of ciprofloxacin, ciclosporin, mycophenolate, tacrolimus and levothyroxine. Sevelamer should be given 3 hr before or 1 hr after taking other drugs to minimise potential pharmacokinetic interaction.
Side Effects
Side effects of Terconazole 0.4% Vag prep :
Vulvovaginal burning, vulvar itching, dysmenorrhoea, genital, body and abdominal pain. Flu-like syndrome with headache, fever, chills and hypotension with doses >80 mg.
Mode of Action
Terconazole disrupts ergosterol synthesis by binding to fungal cytochrome P450. It is active in vitro against Candida spp. and other fungi. It has some antibacterial activity in vitro but not against usual vag flora e.g, lactobacilli.