Tafluprost

Indications

Tafluprost is used for: Elevated Intraocular Pressure

Adult Dose

Elevated Intraocular Pressure Indicated for reducing elevated IOP in patients with open-angle glaucoma or ocular hypertension Instill 1 drop in affected eye(s) once daily in the evening

Child Dose

Renal Dose

Administration

Instill into conjunctival sac of affected eye(s) Do not exceed once daily dosing regimen; more frequent administration of prostaglandin analogs may lessen the IOP lowering effect Reduction of intraocular pressure starts approximately 2 - 4 hours after first administration with maximum effect reached after 12 hr If other topical ophthalmics are prescribed, each should be administered 5 minutes apart

Contra Indications

Precautions

Causes changes to pigmented tissues; most frequently reported changes have been of the iris, eyelid, and eyelashes; pigmentation changes of the iris is likely permanent Increases length, color, thickness, and number of eyelashes Caution with active intraocular inflammation (may exacerbate condition) Macular edema reported; caution in aphakic patients, in pseudophakic patients with a torn posterior lens capsule, or with known risk factors for macular edema. Lactation: Unknown whether distributed in breast milk.

Pregnancy-Lactation

Pregnancy Category: C; teratogenic when administered IV in rats and rabbits Lactation: Unknown whether distributed in breast milk

Interactions

Side Effects

Side effects of Tafluprost : >10% Conjunctival hyperemia (4-20%) 1-10% Ocular stinging (7%), Ocular pruritus/allergic conjunctivitis (5%), Cataract (3%), Growth of eyelashes (2%), Blurred vision (2%)

Mode of Action

Prostaglandin analog; exact mechanism by which it reduces IOP is unknown, but it is thought to increase uveoscleral outflow