Paromomycin

Indications

Paromomycin is used for: Intestinal amoebiasis, Hepatic Coma (Adjunctive), Tapeworm

Adult Dose

Intestinal Amebiasis (E. Histolytica) 25-35 mg/kg/day PO divided q6hr for 5-10 days Effective in acute and chronic but not extraintestinal Hepatic Coma (Adjunctive) 4 g PO qDay in divided doses for 5-6 days Diantomoeba Fragilis 20-30 mg/kg/day PO divided q8hr Tapeworm (T. saginata/T. solium/D. latum/D. caninum) 11 mg/kg PO divided q15min for 4 doses Dwarf Tapeworm 45 mg/kg/dose PO qDay for 5-7 days

Child Dose

E. Histolytica 25-35 mg/kg/day divided q8hr PO for 7 days OR 750 mg/m²/day divided q6hr PO for 5 days Dientamoeba Fragilis 25-30 mg/kg/day PO divided q8hr for 7 days Intestinal Amebiasis 25-35 mg/kg/day PO divided q8hr for 5-10 days Tapeworm (Hymenolepis nana) 45 mg/kg PO qDay for 5-7 days Tapeworm (T. saginata/T. solium/D. latum/D. caninum) 11 mg/kg PO divided q15min for 4 doses Dwarf Tapeworm 45 mg/kg/dose PO qDay for 5-7 days

Renal Dose

Administration

Should be taken with food. Take during meals.

Contra Indications

Hypersensitivity to paromomycin and other aminoglycosides. Intestinal obstruction.

Precautions

Patient w/ ulcerative bowel lesions. Prolonged use may result in overgrowth of non-susceptible organisms. Renal impairment. Pregnancy and lactation.

Pregnancy-Lactation

Pregnancy Category: C Lactation: does not enter breast milk

Interactions

Side Effects

Side effects of Paromomycin : 1-10% Diarrhea Abdominal cramps Nausea Vomiting Heartburn <1% Headache Vertigo Exanthema Rash Pruritus Steatorrhea Secondary enterocolitis Eosinophilia Ototoxicity

Mode of Action

Aminoglycoside; interferes with bacterial protein synthesis by binding to 30S ribosomal subunits; has antibacterial against pathogenic organisms in the GI tract