Paracetamol + Pseudoephedrine + Guaifenesin

Indications

Paracetamol + Pseudoephedrine + Guaifenesin is used for: Temporary Relief of Minor Aches & Pains, Headache, Nasal Congestion

Adult Dose

Temporary Relief of Minor Aches & Pains, Headache, & Nasal Congestion 2 tablets PO q4-6hr; not to exceed 8 capsules/day; not to exceed 1 g acetaminophen/4hr and 4 g Paracetamoln/day

Child Dose

Temporary Relief of Minor Aches & Pains, Headache, & Nasal Congestion >12 years 2 tablets PO q4-6hr; not to exceed 8 capsules/day; not to exceed 1 g acetaminophen/4hr and 4 g Paracetamol/day

Renal Dose

Administration

Contra Indications

Hypersensitivity Within 14 days of MAO inhibitor therapy G-6-PD deficiency Severe hepatic impairment

Precautions

Cardiovascular disease, diabetes mellitus, prostatic hypertrophy & increased intraocular pressure may occur with pseudoephedrine Paracetamol hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose Paracetamol : Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash Guaifenesin is not for administration in persistent cough associated with chronic bronchitis, smoking, asthma, or accompanied with excessive secretions

Pregnancy-Lactation

Pregnancy category: C Lactation: excreted in breast milk, use caution

Interactions

Side Effects

Side effects of Paracetamol + Pseudoephedrine + Guaifenesin : Frequency Not Defined Arrhythmia Palpitations Convulsion Dizziness Drowsiness Excitability Headache Tremor Nausea Vomiting Dermatologic rash Anemia blood dyscrasias (neutropenia, pancytopenia, leukopenia) Bilirubin & alkaline phosphatase may increase Weakness

Mode of Action

Paracetamol blocks pain impulse generation peripherally and may inhibit the generation of prostaglandin in the CNS; reduces fever by inhibiting the hypothalamic heat-regulating center Pseudoephedrine: stimulates the alpha-adrenergic receptors causing bronchodilation & vasoconstriction Guaifenesin: increases respiratory tract fluid secretions and helps to loosen phlegm and bronchial secretions