Paracetamol + Guaifenesin

Indications

Paracetamol + Guaifenesin is used for: Cough, Fever, Headache, Minor Aches & Pains

Adult Dose

Cough, Fever, Headache, Minor Aches & Pains 1 packet (1000mg/400mg) dissolved in 8 oz of hot water q6hr; not to exceed 4 packets/day; consume entire drink within 10-15 minutes

Child Dose

Cough, Fever, Headache, Minor Aches & Pains <12 years Ask a pediatrician >12 years 1 packet dissolved in 8 oz of hot water q6hr; not to exceed 4 packets/day; consume entire drink within 10-15 minutes

Renal Dose

Administration

Contra Indications

Hypersensitivity G-6-PD deficiency Severe hepatic impairment

Precautions

Paracetamol hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose Paracetamol: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash Guaifenesin is not for administration in persistent cough associated with chronic bronchitis, smoking, asthma, or accompanied with excessive secretions

Pregnancy-Lactation

Pregnancy category: C Lactation: excreted in breast milk; use caution

Interactions

Side Effects

Side effects of Paracetamol + Guaifenesin : Frequency Not Defined Dizziness Drowsiness Headache Dermatologic rash Nausea Vomiting Anemia blood dyscrasias (neutropenia, pancytopenia, leukopenia) Bilirubin and alkaline phosphatase may increase

Mode of Action

Paracetamol blocks pain impulse generation peripherally & may inhibit the generation of prostaglandin in the CNS; reduces fever by inhibiting the hypothalamic heat-regulating center Guaifenesin increases respiratory tract fluid secretions & helps to loosen phlegm & bronchial secretions