Paracetamol + Doxylamine + Phenylephrine

Indications

Paracetamol + Doxylamine + Phenylephrine is used for: Sinus Pain, Congestion, Rhinorrhea, Sneezing, Headache

Adult Dose

Sinus Pain, Congestion, Rhinorrhea, Sneezing, Headache 2 capsules PO q4hr; not to exceed 6 doses/day

Child Dose

Sinus Pain, Congestion, Rhinorrhea, Sneezing, Headache >12 years: 2 capsules PO q4hr; not to exceed 6 doses/day

Renal Dose

Administration

Contra Indications

Documented hypersensitivity Asthma Narrow-angle glaucoma Symptomatic prostate hypertrophy Bladder-neck obstruction Stenosing peptic ulcer Known G-6-PD deficiency

Precautions

Paracetamol hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose Doxylamine may exacerbate angle closure glaucoma, hyperthyroidism, peptic ulcer, or urinary tract obstruction; xerostomia may occur Phenylephrine is a vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue. It shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia.

Pregnancy-Lactation

Interactions

Side Effects

Side effects of Paracetamol + Doxylamine + Phenylephrine : Frequency Not Defined Hypertension Reflex tachycardia Severe peripheral & visceral vasoconstriction Dizziness Drowsiness Excitability Headache Restlessness Tremor Dermatologic rash Anemia blood dyscrasias (neutropenia, pancytopenia, leukopenia) Bilirubin & alkaline phosphatase may increase Dry mouth, throat, and nose Thickening of mucus in nose or throat

Mode of Action

Paracetamol: Blocks pain impulse generation peripherally & may inhibit the generation of prostaglandin in the CNS; reduces fever by inhibiting hypothalamic heat-regulating center Doxylamine: Competitively blocks histamine from binding to H1 receptors; significant antimuscarinic activity & penetrates CNS, which causes pronounced tendency to induce sedation Phenylephrine: Vasoconstrictor & decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue; shrinks swollen mucous membranes, reduces nasal congestion & tissue hyperemia