Paracetamol + Doxylamine + Phenylephrine
Indications
Paracetamol + Doxylamine + Phenylephrine is used for:
Sinus Pain, Congestion, Rhinorrhea, Sneezing, Headache
Adult Dose
Sinus Pain, Congestion, Rhinorrhea, Sneezing, Headache
2 capsules PO q4hr; not to exceed 6 doses/day
Child Dose
Sinus Pain, Congestion, Rhinorrhea, Sneezing, Headache
>12 years: 2 capsules PO q4hr; not to exceed 6 doses/day
Renal Dose
Administration
Contra Indications
Documented hypersensitivity
Asthma
Narrow-angle glaucoma
Symptomatic prostate hypertrophy
Bladder-neck obstruction
Stenosing peptic ulcer
Known G-6-PD deficiency
Precautions
Paracetamol hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose
Doxylamine may exacerbate angle closure glaucoma, hyperthyroidism, peptic ulcer, or urinary tract obstruction; xerostomia may occur
Phenylephrine is a vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue. It shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia.
Pregnancy-Lactation
Interactions
Side Effects
Side effects of Paracetamol + Doxylamine + Phenylephrine :
Frequency Not Defined
Hypertension
Reflex tachycardia
Severe peripheral & visceral vasoconstriction
Dizziness
Drowsiness
Excitability
Headache
Restlessness
Tremor
Dermatologic rash
Anemia blood dyscrasias (neutropenia, pancytopenia, leukopenia)
Bilirubin & alkaline phosphatase may increase
Dry mouth, throat, and nose
Thickening of mucus in nose or throat
Mode of Action
Paracetamol: Blocks pain impulse generation peripherally & may inhibit the generation of prostaglandin in the CNS; reduces fever by inhibiting hypothalamic heat-regulating center
Doxylamine: Competitively blocks histamine from binding to H1 receptors; significant antimuscarinic activity & penetrates CNS, which causes pronounced tendency to induce sedation
Phenylephrine: Vasoconstrictor & decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue; shrinks swollen mucous membranes, reduces nasal congestion & tissue hyperemia