Nandrolone

Indications

Nandrolone is used for: Postmenopausal osteoporosis, Metastatic breast cancer, Anaemia of chronic renal failure, Anaemia in chemotherapy patients

Adult Dose

Intramuscular As anabolic after debilitating illness; Postmenopausal osteoporosis; Metastatic breast cancer Adult: As decanoate: 25-100 mg once every 3-4 wk. Anaemia of chronic renal failure Adult: As decanoate: 50-200 mg wkly. Anaemia in chemotherapy patients Adult: 50-150 mg wkly.

Child Dose

Renal Dose

Administration

Contra Indications

Prostatic or breast carcinoma (male); nephrosis, porphyria; infants, pregnancy and lactation.

Precautions

Monitor diabetic patients carefully. Conditions influenced by oedema (e.g. CV disease, migraine, seizure disorder, renal impairment). Hepatic impairment. Elderly. Discontinue if signs of virilisation in women occur. Monitor skeletal maturation in children.

Pregnancy-Lactation

Interactions

May increase effects of oral anticoagulants, insulin, oral antidiabetic agents, adrenal steroid, adrenocorticotropic hormone (ACTH).

Side Effects

Side effects of Nandrolone : Male: Postpubertal: Acne, gynaecomastia, bladder irritability, priapism, insomnia, chills, decreased libido, hepatic dysfunction, nausea, diarrhoea, prostatic hyperplasia. Prepubertal: Acne, virilism, chills, insomnia, hyperpigmentation, diarrhoea, nausea. Female: Virilism, hypercalcaemia, nausea, diarrhoea, chills, insomnia, iron deficiency anaemia, hepatic dysfunction.

Mode of Action

Nandrolone is an anabolic steroid. It promotes tissue-building processes and protein anabolism. It also stimulates erythropoeitin production, causing an increase in haemoglobin and RBC volume.