Magnesium Sulphate inj

Indications

Magnesium Sulphate inj is used for: Eclampsia, Cerebral palsy, Hypomagnesemia, Torsades de pointes, Barium poisoning

Adult Dose

Adult: IV Hypomagnesaemia Symptomatic deficiency: 1-2 g over 5-60 mins, then maintain at 0.5-1 g/hr if needed. Severe: 1-2 g/hr for 3-6 hr, then 0.5-1 g/hr as needed to correct deficiency. Torsades de pointes W/ pulses: Loading dose: 1-2 g over 5-60 mins, then maintain at 0.5-1 g/hr as needed. Pulseless: 1-2 g over 5-20 mins. Barium poisoning 1-2 g. Cerebral oedema 2.5 g. Eclampsia Loading dose: 4-5 g over 10-15 mins, followed by either a continuous infusion of 1 g/hr or deep IM doses of 4-5 g into alternate buttocks 4 hrly. If seizure recurs, an additional IV dose of 2-4 g may be given. Not to exceed 30-40 g/24 hr. IM Hypomagnesaemia Mild deficiency: 1 g 6 hrly for 4 doses. Severe deficiency: Up to 250 mg/kg w/in 4 hr.

Child Dose

Renal Dose

Administration

Contra Indications

Parenteral: Heart block, severe renal impairment, myocardial damage.

Precautions

Renal impairment, myasthaenia gravis, digitalised patients; pregnancy. Monitor serum-magnesium concentrations.

Pregnancy-Lactation

Interactions

Enhances neuromuscular blockers, digitalis glycosides.

Side Effects

Side effects of Magnesium Sulphate inj : Hypermagnesaemia characterised by nausea, vomiting, flushing, thirst, hypotension, drowsiness, confusion, slurred speech, double vision, bradycardia, muscle weakness. Hypocalcaemia; paralytic ileus.

Mode of Action

Magnesium sulfate decreases levels of acetylcholine in motor nerve terminals. It also acts on the myocardium by decreasing the rate of SA node impulse formation and prolonging the conduction time.