Magaldrate

Indications

Magaldrate is used for: Peptic ulcers, GERD, Heartburn, Gastritis

Adult Dose

Heartburn, Sour Stomach, & Acid Indigestion 5-10 mL (1-2 teaspoonfuls; 540-1080 mg) between meals and at bed time. not to exceed 80 mL (16 teaspoonfuls) in 24-hour period PO: 1-3 tablets between meals and at bed time.

Child Dose

Safety & efficacy not established

Renal Dose

Administration

Take between meals & at bedtime.

Contra Indications

Magaldrate is contraindicated in patients with known hypersensitivity to magnesium and aluminium. It is also contraindicated in patients with impaired renal functions.

Precautions

Care should be taken in decreased kidney function, hypophosphataemia and weak people. Lactation: not known whether excreted in breast milk, use caution

Pregnancy-Lactation

Interactions

Magaldrate may negatively influence drugs like tetracyclines, benzodiazepines, and indomethacin. High doses or prolonged usage may lead to an increment of defecation and a reduction in feces consistence. In some cases it can alter the functionality of the gastrointestinal tract, occasionally provoking constipation or diarrhea.

Side Effects

Side effects of Magaldrate : >10% Aluminum oxide Chalky taste, Constipation, Fecal impaction, Stomach cramps Frequency Not Defined Aluminum oxide Nausea, Vomiting, Aluminum intoxication, Hypophosphatemia, Osteomalacia, Magnesium oxide Diarrhea, Hypermagnesemia

Mode of Action

Magaldrate is a hydroxymagnesium aluminate complex that is rapidly converted in gastric acid to magnesium and aluminium hydroxide, which is poorly absorbed and provides a sustained antacid effect with balanced efects on intestinal motility; increases lower esophageal sphincter tone and inhibits smooth muscle contraction and gastric emptying.