Mafenide
Indications
Mafenide is used for:
Burn Treatment
Adult Dose
Topical/Cutaneous
Treatment and prophylaxis of infection in second- and third-degree burns
Adult: As 8.5% cream: Apply a layer approx 1/16 inch 1-2 times daily. Continue until wound healing progresses or burn site ready for grafting. As 5 % soln: Wet an 8-ply burn dressing w/ soln and cover graft area.
Keep dressing wet by using syringe or irrigation tubing (4 hrly or as necessary) or by moistening the dressing (6-8 hrly or as necessary). Continue until autograft vascularisation occurs and wound healing progresses. Wound dressing may be left in place for up to 5 days.
Child Dose
Topical/Cutaneous
Child: As 8.5% cream: Apply a layer approx 1/16 inch 1-2 times daily. Continue until wound healing progresses or burn site ready for grafting.
>3 mth: As 5 % soln: Wet an 8-ply burn dressing w/ soln and cover graft area.
Renal Dose
Administration
Contra Indications
Hypersensitivity to sulfonamides.
Precautions
Hypersensitivity
Use extreme caution in patients with sulfonamide allergy
E. coli & Proteus spp. appear to be less sensitive
Prolonged use may result in fungal or bacterial superinfection including C. difficile-associated diarrhea and pseudomembranous colitis
Pregnancy/women of childbearing potential-not recommended in women of childbearing potential unless burned area >20% BSA or benefits justify possible risks to the fetus
G-6-PD deficiency; may result in hemolytic anemia
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Not known whether distributed into breast milk, discontinue drug or do not nurse
Interactions
Side Effects
Side effects of Mafenide :
Frequency Not Defined
Application site reactions
Edema
Facial edema
Diarrhea
Excoriation
Pain
Blisters
Burning sensation
Hypersensitivity
Bone marrow suppression
Anemia
Eosinophilia
Porphyria
Hyperventilation
Hemolytic anemia
Allergic reactions
Systemic acidosis with tachypnea
Mode of Action
Mafenide is a short-acting sulfonamide topical antibacterial agent that has a wide spectrum of activity. It has no definite mechanism of action, however, it appears to interfere w/ bacterial cellular metabolism. It has bacteriostatic action against many gm+ve and gm-ve organisms, including Pseudomonas aeruginosa and some anaerobes.