Latanoprost .005% + Timolol 0.5% Eye prep
Indications
Latanoprost .005% + Timolol 0.5% Eye prep is used for:
Open-angle glaucoma, Ocular HTN
Adult Dose
Ophthalmic
Ocular hypertension, Open-angle glaucoma
Adult: As eye preparation containing latanoprost 0.005% and timolol 0.5%:
Instill 1 drop into the affected eye(s) once daily.
Not to be used as an initial therapy.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Prolonged treatment with latanoprost may change eye colour by increasing the amount of brown pigment in the iris especially in patients with mixed coloured irides; regular eye examination is recommended. Caution when used in aphakic patients due to risk of macular oedema. Contact lenses should be removed during application and reinserted at least 15 minutes after application. May cause transient blurring of vision; patients should not drive or operate machinery until this resolves. Pregnancy and lactation.
Pregnancy-Lactation
Pregnancy Category: weigh risk/benefit
Lactation: use caution
Interactions
Additive effect on the intraocular pressure and other systemic effects may occur when used with oral beta-blockers, calcium channel blockers, guanethidine, antiarrhythmics, digitalis glycosides or parasympathomimetics. Concurrent use of >2 ophthalmic prostaglandin analogues may lead to paradoxical increase in intraocular pressure. Mydriasis may occur when used concurrently with epinephrine. beta-blocker may increase hypoglycaemic effect of antidiabetic agents.
Side Effects
Side effects of Latanoprost .005% + Timolol 0.5% Eye prep :
>10%
Ocular burning (11%)
1-10%
Conjunctival hyperemia (9%), Local itching, Tearing, Dry eye, Ocular discomfort, Increase in iris pigmentation (related to latanoprost)
Mode of Action
Latanoprost is an analogue of prostaglandin F2alpha; it reduces intraocular pressure (IOP) by increasing outflow of aqueous humour. Timolol is a non-selective adrenergic blocker. It lowers IOP by decreasing the formation of aqueous by the ciliary epithelium.