Lactic acid + Citric acid + Potassium bitartrate vaginal
Indications
Lactic acid + Citric acid + Potassium bitartrate vaginal is used for:
Contraception, To prevent pregnancy
Adult Dose
Contraception
Indicated for prevention of pregnancy in females of reproductive potential for use as an on-demand contraceptive method
Apply 1 prefilled applicator (5 grams) vaginally immediately before or up to 1 hr before each act of vaginal intercourse
If >1 act of vaginal intercourse occurs within 1 hr, an additional dose must be applied
Child Dose
Renal Dose
Administration
Intravaginal Administration
May use during any part of the menstrual cycle
May use as soon as it is safe to resume vaginal intercourse after childbirth, abortion, or miscarriage
Contra Indications
Should be avoided in women who have had recurrent urinary tract infections or abnormalities or are using a vaginal ring.
Precautions
Cystitis and pyelonephritis
Cystitis, pyelonephritis, or other upper UTI may occur
Avoid use of in females of reproductive potential with a history of recurrent UTI or urinary tract abnormalities
Pregnancy-Lactation
Pregnancy
Do not use during pregnancy
Discontinue during pregnancy
No data available with the use in pregnant females or animals
Lactation
No data available on the presence of lactic acid, citric acid, and potassium bitartrate or their metabolites in human milk, or effects on breastfeeding or milk production
Interactions
Side Effects
Side effects of Lactic acid + Citric acid + Potassium bitartrate vaginal :
>10%
Vulvovaginal burning sensation (18%)
Vulvovaginal pruritus (14.5%)
1-10%
Local discomfort in male partners (9.8%)
Vulvovaginal mycotic infection (9.1%)
Urinary tract infection (UTI) (9%)
Vulvovaginal discomfort (9%)
Bacterial vaginosis (8.4%)
Vaginal discharge (5.5%)
Genital discomfort (4.1%)
Dysuria (3.1%)
Vulvovaginal pain (2.1%)
Mode of Action
Vaginal pH range is 3.5-4.5 and semen pH range is 7.2-8
Introduction of semen into the vagina causes increased pH (>6) owing to ejaculate alkalinity; the alkaline pH neutralizes the normally acidic vaginal environment allowing spermatozoa survival
Vaginal pH lowering effect of lactic acid/citric acid/potassium bitartrate causes reduced sperm motility and contributes to intravaginal contraceptive activity