Inositol (Myo-inositol)

Indications

Inositol (Myo-inositol) is used for: Polycystic ovary syndrome (PCOS), anovulation, insulin resistance, metabolic syndrome, diabetes, gestational diabetes

Adult Dose

Oral 3 times daily for at least 3 months

Child Dose

Renal Dose

Administration

Can be taken with or without foods

Contra Indications

Patients with a known hypersensitivity to any component of this product.

Precautions

Patient with diabetes should be cautious about use of this medication.

Pregnancy-Lactation

Inositol is possibly safe when taken by mouth during pregnancy. There isn't enough reliable information to know if Inositol (Myo-inositol) is safe to use when breast-feeding.

Interactions

Concomitant use of anti-diabetic drug and Inositol (Myo-inositol) may result in more reduced blood glucose than only anti-diabetic drug therapy.

Side Effects

Side effects of Inositol (Myo-inositol) : Well tolerated in recommended dose. Only mild gastrointestinal side effects can be shown with higher doses.

Mode of Action

Inositols are important molecules in promoting female fertility and in sustaining physiological pregnancy. Myo-inositol, a major form of Inositol, has an established role in human physiology. Myo-inositol represents the most abundant inositol isomer in humans, and it is commonly found in almost every tissue, particularly in brain, blood, fat, kidney, lung, ovaries, and testes, where it participates in several cellular pathways. Inositol (Myo-inositol) as second messenger of gonadotropins and insulin, it guarantees the correct development of oocytes and the progression of embryogenesis. Available evidence demonstrates that the supplementation with Inositol (Myo-inositol) enhances the probability of achieving pregnancy and reduces the onset of adverse maternal effects and neonatal outcomes. Specifically, in the pursuit of pregnancy, Inositol (Myo-inositol) proved to induce ovulation and restore the physiological menstrual cycle in infertile women, particularly in those with PCOS. Moreover, Inositol (Myo-inositol) supplementation is also useful for women undergoing ART, improving oocyte and embryo quality. During pregnancy, Inositol (Myo-inositol) reduces the risk of altered metabolic conditions like GDM, which may lead to miscarriages or stillborn babies. In addition, Inositol (Myo-inositol) seems to reduce the risk of NTDs in folate-resistant women.