Idoxuridine 0.1% Eye prep
Indications
Idoxuridine 0.1% Eye prep is used for:
Herpes simplex keratitis
Adult Dose
Ophthalmic
Herpes simplex keratitis
Adult: As 0.1% soln: Instill 1 drop in the affected eye(s) every hr. Taper to every 2 hr or 4 times daily. Continue treatment for at least 7 days.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Deep ulceration of the stromal layers of the cornea. Avoid prolonged use. Pregnancy and lactation.
Pregnancy-Lactation
Interactions
Corticosteroids may accelerate spread of viral infection.
Side Effects
Side effects of Idoxuridine 0.1% Eye prep :
Ophthalmic: Irritation; inflammation of the eye or eyelids; pain; photophobia; pruritus; conjunctivitis; oedema. Rarely, lachrymal duct occlusion and hypersensitivity reactions. Corneal damage (prolonged use).
Mode of Action
Idoxuridine, a pyrimidine nucleoside structurally related to thymidine, inhibits viral replication by substituting itself for thymidine in viral DNA. It is active against herpes simplex and varicella zoster viruses, and has also been shown to inhibit vaccinia virus, cytomegalovirus and adenovirus.