Ibuprofen + Phenylephrine
Indications
Ibuprofen + Phenylephrine is used for:
Allergy, Cold Symptoms
Adult Dose
Allergy & Cold Symptoms
1 tab PO q4hr PRN while symptoms persist
Not to exceed 6 tablets/24 hr
Child Dose
Allergy & Cold Symptoms
<12 years: Safety and efficacy not established
>12 years: 1 tab PO q4hr PRN while symptoms persist; not to exceed 6 tablets/24 hr
Renal Dose
Administration
Take with food or milk if stomach upset occurs
Contra Indications
Hypersensitivity
History of induce asthma or urticaria with NSAIDs
Immediately before or after heart surgery
Within 2 weeks of MAO inhibitor therapy
Precautions
Caution with hypertension, heart disease, hepatic or renal impairment, asthma, thyroid disease, diabetes, or BPH
Ibuprofen
May increase risk for GI ulceration
Caution in coadministration with antiplatelets/anticoagulants
NSAIDS, except aspirin, increase risk of heart attack, heart failure, and stroke; which can be fatal; the risk is higher if patients use more than it was directed or for longer than needed; may decrease benefit of cardioprotective low-dose aspirin
Use caution in patients with high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, thyroid disease, diabetes, glaucoma, have trouble urinating due to an enlarged prostate gland, or had a stroke
Patients should inform healthcare professional if they experience symptoms of heart problems or stroke, chest pain, trouble breathing, weakness in one part or side of body, slurred speech, leg swelling
Phenylephrine
May exacerbate poorly controlled hypertension
Caution if underlying cardiovascular risks present
Pregnancy-Lactation
Pregnancy & Lactation
Do not take NSAIDs within 3 months before delivery because of risk of premature closure of the ductus arteriosus
Lactation: NSAIDs excreted in breast milk, AAP states compatible with breastfeeding
Interactions
Side Effects
Side effects of Ibuprofen + Phenylephrine :
Frequency Not Defined
GI upset
Insomnia
Hemolytic anemia
Aplastic anemia
Arrhythmia
Bronchospasm
CHF
Efoliative dermatitis
Constipation
Hypertension
Neutropenia
Thromboembolism
Abdominal pain
Anxiety
CNS stimulation
Hepatotoxicity
Dizziness
Mode of Action
Ibuprofen: Inhibits synthesis of prostaglandins by inhibiting cyclooxygenase (COX-1, COX-2); may inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytoking activity, and inhibit neutrophil aggregation, which in turn may result in anti-inflammatory activity
Phenylephrine is a vasoconstrictor and decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue; shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia