Ibuprofen + Phenylephrine

Indications

Ibuprofen + Phenylephrine is used for: Allergy, Cold Symptoms

Adult Dose

Allergy & Cold Symptoms 1 tab PO q4hr PRN while symptoms persist Not to exceed 6 tablets/24 hr

Child Dose

Allergy & Cold Symptoms <12 years: Safety and efficacy not established >12 years: 1 tab PO q4hr PRN while symptoms persist; not to exceed 6 tablets/24 hr

Renal Dose

Administration

Take with food or milk if stomach upset occurs

Contra Indications

Hypersensitivity History of induce asthma or urticaria with NSAIDs Immediately before or after heart surgery Within 2 weeks of MAO inhibitor therapy

Precautions

Caution with hypertension, heart disease, hepatic or renal impairment, asthma, thyroid disease, diabetes, or BPH Ibuprofen May increase risk for GI ulceration Caution in coadministration with antiplatelets/anticoagulants NSAIDS, except aspirin, increase risk of heart attack, heart failure, and stroke; which can be fatal; the risk is higher if patients use more than it was directed or for longer than needed; may decrease benefit of cardioprotective low-dose aspirin Use caution in patients with high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, thyroid disease, diabetes, glaucoma, have trouble urinating due to an enlarged prostate gland, or had a stroke Patients should inform healthcare professional if they experience symptoms of heart problems or stroke, chest pain, trouble breathing, weakness in one part or side of body, slurred speech, leg swelling Phenylephrine May exacerbate poorly controlled hypertension Caution if underlying cardiovascular risks present

Pregnancy-Lactation

Pregnancy & Lactation Do not take NSAIDs within 3 months before delivery because of risk of premature closure of the ductus arteriosus Lactation: NSAIDs excreted in breast milk, AAP states compatible with breastfeeding

Interactions

Side Effects

Side effects of Ibuprofen + Phenylephrine : Frequency Not Defined GI upset Insomnia Hemolytic anemia Aplastic anemia Arrhythmia Bronchospasm CHF Efoliative dermatitis Constipation Hypertension Neutropenia Thromboembolism Abdominal pain Anxiety CNS stimulation Hepatotoxicity Dizziness

Mode of Action

Ibuprofen: Inhibits synthesis of prostaglandins by inhibiting cyclooxygenase (COX-1, COX-2); may inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytoking activity, and inhibit neutrophil aggregation, which in turn may result in anti-inflammatory activity Phenylephrine is a vasoconstrictor and decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue; shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia