Homatropine Hydrobromide Eye prep
Indications
Homatropine Hydrobromide Eye prep is used for:
Mydriasis and cycloplegia for refraction, Dilatation of pupil
Adult Dose
Ophthalmic
Mydriasis and cycloplegia for refraction
Adult: Instill 1 or 2 drops of 2% solution, may repeat at 10-15 min intervals if necessary; not to exceed 5 doses
Uveitis
Adult: Instill 1-2 drops of 2% bid-tid up to every 3-4 hr as needed.
Child Dose
Ophthalmic
Mydriasis and cycloplegia for refraction
Child: Instill 1 drop of 2% soln immediately before the procedure, repeat at 10-min intervals if necessary.
Uveitis
Child: >2 yr: instill 1 drop of 2% soln bid.
Renal Dose
Administration
Contra Indications
Acute haemorrhage; narrow-angle glaucoma; primary glaucoma; predisposition to glaucoma; hypersensitivity.
Precautions
Hypertension; cardiac disease; unstable CV status in acute haemorrhage; increased intraocular pressure; obstructive uropathy; paralytic ileus; ulcerative colitis; elderly; infants; young child; pregnancy. Finger pressure should be applied on the lachrymal sac for 1-2 minutes after instillation to reduce systemic absorption.
Lactation: Excretion in milk unknown; not recommended
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Excretion in milk unknown; not recommended
Interactions
Effects may be increased by drugs with antimuscarinic effect such as; some antihistamines; phenothiazines; antipsychotics; TCAs; MAOIs or parasympathomimetics.
Side Effects
Side effects of Homatropine Hydrobromide Eye prep :
Blurred vision; photophobia; increased intraocular pressure. Prolonged use may cause local irritation characterized by follicular conjunctivitis, vascular congestion, oedema, exudate and eczematoid dermatitis.
Mode of Action
Homatropine, a tertiary amine antimuscarinic, produces dilation and loss of accommodation by blocking the response of iris sphincter muscle and the accommodative ciliary muscle to cholinergic stimulation.