Hepatitis A Vaccine (HAV Antigen)

Indications

Hepatitis A Vaccine (HAV Antigen) is used for: Active immunisation against Hepatitis A virus

Adult Dose

Intramuscular Active immunisation against hepatitis A Adult: 2-dose vaccination series: 1 mL IM; separate the 2 doses by 6-12 months

Child Dose

Intramuscular Active immunisation against hepatitis A Child: Indicated as routine vaccination for children at least 12 months of age (ACIP guidelines) <12 months: Not indicated Routine vaccination (2-dose series): 0.5 mL IM initiated at aged 12 through 23 months; separate the 2 doses by 6-12 months Children who have received 1 dose before age 24 months, should receive a second dose 6-12 months after the first dose Catch up schedule For any person >2 yr who has not already received hepatitis A vaccine series, give 2 doses separated by 6-18 months if immunity against hepatitis A virus infection is desired Minimum interval between the 2-dose series is 6 months

Renal Dose

Administration

Contra Indications

Hypersensitivity. Vaccines prepared in egg cultures are contraindicated in patients with hypersensitivity reactions to egg. Severe immunodeficiency. Malignant disease being treated with chemotherapy or radiotherapy and for at least 6 mth after stopping treatment. Patients with compromised immune system such as those on high-dose systemic corticosteroids, immunosuppressants or HIV positive.

Precautions

Alcohol or disinfectant used for cleaning the skin prior to inj should be allowed to evaporate completely before vaccination to prevent vaccine inactivation. Lactation: not established

Pregnancy-Lactation

Interactions

Reduced response to vaccination when used concurrently with immunosuppressants such as corticosteroids or antineoplastics.

Side Effects

Side effects of Hepatitis A Vaccine (HAV Antigen) : >10% Injection site tenderness (3-56%), erythema (1-22%), warmth (1-17%), swelling (9-11%), Irritability (11-36%), Anorexia (1-19%), Drowsiness (15-17%), Headache (1-16%), Fever > 100.4 F (9-11%) 1-10% URI (1-10%), Otitis media (8%), Rhinorrhea (6%), Diarrhea (1-6%), Cough (1-5%), Rash (1-5%), Weakness/fatigue (4%), Vomiting (1-4%), Fever > 102 F (3%), Crying (2%) <1% Hematoma, Incr. CPK, Photophobia, Vertigo Potentially Fatal: Anaphylaxis.

Mode of Action

Hepatitis A antigen is prepared from formaldehyde-inactivated hepatitis A virus grown in human diploid cells. It is used for active immunisation against hepatitis A infection.