Gentamicin 0.3% E/E prep
Indications
Gentamicin 0.3% E/E prep is used for:
Superficial ophthalmic infections, Otitis externa,
Adult Dose
Ophthalmic
Superficial ophthalmic infections
Adult: As eye drops: Instill 1-2 drops into affected eye up to 6 times daily.
For severe infections, initially, 1-2 drops every 15 min, reducing the frequency gradually as the infection is controlled.
As eye oint: Place a small amount into the conjunctival sac 2-3 times daily.
Otic/Aural
Otitis externa
Adult: As ear drops: Instill 2-3 drops in the affected ear 3-4 times a day and at night.
Child Dose
Ophthalmic
Superficial ophthalmic infections
Child: As eye drops: Instill 1-2 drops into affected eye up to 6 times daily.
For severe infections, initially, 1-2 drops every 15 min, reducing the frequency gradually as the infection is controlled.
As eye oint: Place a small amount into the conjunctival sac 2-3 times daily.
Otic/Aural
Otitis externa
Child: As ear drops: Instill 2-3 drops in the affected ear 3-4 times a day and at night.
Renal Dose
Administration
Contra Indications
History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment, perforated ear drum.
Precautions
Concurrent use of neuromuscular blocking agents; myasthenia gravis, parkinsonism; conditions predisposing to ototoxicity and nephrotoxicity; lactation. Monitor plasma concentrations of gentamicin in patients receiving high doses or prolonged courses, in infants, elderly, patients with renal impairment, cystic fibrosis or significant obesity. Monitor auditory and renal functions.
Lactation: safety in nursing infants unknown
Pregnancy-Lactation
Pregnancy Category: C
Lactation: safety in nursing infants unknown
Interactions
Additive effect w/ other neurotoxic and/or nephrotoxic drugs including cephalosporins, methicillin, amphotericin B, ciclosporin, cisplatin, potent diuretics (e.g. ethacrynic acid, furosemide) and neuromuscular blocking agents (e.g. succinylcholine, tubocurarine). May potentiate the effect of anticoagulants (e.g. warfarin, phenindione). May antagonise the effect of neostigmine and pyridostigmine. Increased risk of hypocalcaemia w/ bisphosphonates. Increased risk of neuromuscular blockade w/ botulinum toxin. Indometacin may increase the plasma concentration of gentamicin in neonates.
Side Effects
Side effects of Gentamicin 0.3% E/E prep :
Allergic contact dermatitis, Transient irritation, burning, stinging, Increased redness, lacrimation
Mode of Action
Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.