Fluormetholone 0.1% + Neomycin Sulphate 0.5% Eye prep
Indications
Fluormetholone 0.1% + Neomycin Sulphate 0.5% Eye prep is used for:
Allergic and inflammatory conditions of the eye
Adult Dose
Adult: Instil 1-2 drops 2-4 times/day.
May increase dose to 4 hrly in severe cases during the initial 24-48 hr.
Child Dose
Renal Dose
Administration
Contra Indications
Viral diseases of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis), Vaccinia and Varicella, mycobacterial eye infection, ocular fungal infections, untreated eye infections; hypersensitivity.
Precautions
Glaucoma (check intraocular pressure periodically), history of herpes simplex fungal or bacterial infections. Not to be used in mustard gas keratitis and Sjogren's keratoconjunctivitis. May cause corneal and scleral thinning which may lead to perforation in serious cases. Use of steroids after cataract surgery may prolong healing time and increase bleb formation. Pregnancy, lactation; children <2 yr.
Pregnancy-Lactation
Interactions
Side Effects
Side effects of Fluormetholone 0.1% + Neomycin Sulphate 0.5% Eye prep :
Elevated intraocular pressure, optic nerve damage, postsubcapsular cataract formation, delayed wound healing, uveitis, perforation of the globe, keratitis, conjunctivitis, corneal ulcers, loss of accommodation, secondary ocular infections, rarely systemic hypercorticoidism.
Mode of Action
Fluorometholone suppresses the migration of polymorphonuclear leukocytes and reversal of increased capillary permeability thus decreasing inflammation.
Neomycin is an aminoglycoside antibiotic. It binds to 30S ribosomal subunits of bacterial ribosome thus inhibiting protein synthesis and generating errors in genetic code transcription causing cell death. It acts against many gram-negative aerobes and some gram-positive aerobes. It lacks activity against fungi, viruses and most anaerobic bacteria.