Fluocinolone Acetonide + Clioquinol topical

Indications

Fluocinolone Acetonide + Clioquinol topical is used for: Inflammatory skin conditions, such as, eczema, dermatitis, psoriasis, corticosteroid-responsive dermatoses

Adult Dose

Topical/Cutaneous Corticosteroid-responsive dermatoses Adult: As 0.0025-0.025% cream/gel/lotion/ointment/scalp lotion: Apply onto affected area(s) 3-4 times daily.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity; child <2 yr. Do not apply on eczematous or broken skin and perforated tympanic membrane. Primary infectious (bacterial, viral, fungal) ulcers, acne vulgaris. Neonates.

Precautions

Children, elderly, hepatic failure. Prolonged use on the face; contact with eyes. Pregnancy, lactation. Can stain fabric and skin. Avoid contact with eyes; avoid prolonged use. Chronic topical corticosteroid therapy may interfere with growth & development in pediatric patients. Not effective in the treatment of fungal infections of the scalp or nails.

Pregnancy-Lactation

Interactions

Side Effects

Side effects of Fluocinolone Acetonide + Clioquinol topical : Prolonged admin causes epidermal thinning, telangiectasia and striae (especially face and flexures). Application on eyelid and surrounding skin can cause raised intraocular pressure, cataracts, glaucoma, corneal ulcers and raised intracranial pressure. Systemic absorption with adrenal suppression may be seen when applied over large areas, when skin is broken or under occlusive dressing. Contact dermatitis, perioral dermatitis, papular disorder, mild depigmentation. Severe irritation or hypersensitivity. Cross-sensitivity with other halogenated hydroxyquinolines. May discolour fair hair. Potentially Fatal: May cause severe neurotoxicity.

Mode of Action

Fluocinolone topical corticosteroids which has local anti-inflammatory action, immunosuppressant and antimitotic actions. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation. Clioquinol is a halogenated hydroxyquinoline with antibacterial and antifungal activity.