Fluconazole 0.3% Eye prep

Indications

Fluconazole 0.3% Eye prep is used for: Fungal corneal ulcers, Fungal keratitis, Fungal eye infections

Adult Dose

Adult: 1 - 2 drops to be instilled into the affected eye 5 times daily.

Child Dose

Renal Dose

Administration

Contra Indications

The drug is contraindicated in patients with hypersensitivity to azoles.

Precautions

Use of fluconazole may result in overgrowth of non-susceptible strains of candida other than C. albicans.

Pregnancy-Lactation

Interactions

May increase plasma concentrations of oral hypoglycaemics (e.g. tolbutamide, glyburide, glipizide), phenytoin, theophylline, tofacitinib, rifabutin. May increase prothrombin time w/ anticoagulants. May cause significant increase in ciclosporin levels in renal transplant patients w/ or w/o renal impairment. Rifampicin reduces fluconazole levels. May increase risk of nephrotoxicity w/ tacrolimus. May increase the effect of short-acting benzodiazepines (e.g. midazolam). Potentially Fatal: Increased risk of cardiac arrhythmias or QT prolongation w/ terfenadine, cisapride, astemizole, pimozide, quinidine, halofantrine and erythromycin.

Side Effects

Side effects of Fluconazole 0.3% Eye prep : This drug is generally well tolerated. Eosinophillia has been reported in some patients.

Mode of Action

Fluconazole decreases ergosterol synthesis by interfering w/ cytochrome P450 activity, thus inhibiting cell membrane formation of susceptible fungi including B. dermatitidis, Candida spp., C. immitis, C. neoformans, Epidermophyton spp., H. capsulatum, Micosporum spp., Trichophyton spp.