Flavoxate Hydrochloride
Indications
Flavoxate Hydrochloride is used for:
Cystitis, Urinary incontinence, Urgency and frequency, Bladder spasms, Dysuria, Nocturia, Suprapubic pain, Prostatitis, Urethritis
Adult Dose
Oral
Adult:
Overactive Bladder
Indicated for dysuria, increased urinary frequency/incontinence, nocturia, suprapubic pain, urinary incontinence, urinary tract irritation, urinary urgency
100-200 mg PO q6-8hr
Child Dose
Dysuria, Urinary Frequency
Indicated for dysuria, increased urinary frequency, nocturia, suprapubic pain, urinary incontinence, urinary tract irritation, urinary urgency
<12 years: Not recommended; safety and efficacy not established
>12 years: 100-200 mg PO q6-8hr
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Pyloric or duodenal obstruction; obstructive intestinal lesions or ileus; achalasia; GI haemorhrage or obstructive uropathies of the lower urinary tract; myasthenia gravis; severe ulcerative colitis; toxic megacolon; glaucoma; children <12.
Precautions
May affect ability to drive or operate machinery. May worsen hyperthyroidism, coronary artery disease, congestive heart failure, prostatic hypertrophy, arrhythmias, tachycardia. Pregnancy; lactation; elderly; autonomic neuropathy; hiatus hernia with reflux esophagitis, hepatic and renal impairment.
Lactation: not known if excreted in breast milk, use caution
Pregnancy-Lactation
Pregnancy Category: B
Lactation: not known if excreted in breast milk, use caution
Interactions
Amantadine, some antihistamines, phenothiazine antipsychotics, tricyclic antidepressants, MAOIs; parasympathomimetics. May decrease gastric motility thus decreasing absorption of certain drugs. May antagonise the GI effects of cisapride, domperidone, metoclopramide.
Side Effects
Side effects of Flavoxate Hydrochloride :
Increased intraocular pressure; difficulty in ocular accommodation; blurred vision; dry mouth and throat; GI disturbances; nervousness; vertigo; headache; fatigue; confusion; hypersensitivity reactions; dysuria; tachycardia; palpitation; hyperpyrexia; eosinophilia; leukopenia, abdominal pain, constipation and difficulty in concentrating.
Mode of Action
Flavoxate is a tertiary amine that acts as a smooth muscle relaxant; it also has antimuscarinic effects. It exhibits local anaesthetic, analgesic and spasmolytic effects.