Fenoldopam

Indications

Fenoldopam is used for: Malignant Hypertension, Hypertensive Emergencies

Adult Dose

Severe/Malignant Hypertension, Hypertensive Emergencies Initiate dosing at 0.01 to 0.3 mcg/kg/min by continuous IV infusion Titrate by 0.05-0.1 mcg/kg/min q15min or longer until target blood pressure reached; up to 1.6 mcg/kg/min used in clinical trials; may continue maintenance infusion for up to 48 hr In hospital use only

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity to fenoldopam and sulfite

Precautions

Causes a dose-related tachycardia, particularly with infusion rates above 0.1 mcg/kg/min Monitor potassium levels Increased intraocular pressure in patients with glaucoma or intraocular hypertension Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms in susceptible patients

Pregnancy-Lactation

Pregnancy Category: B Lactation: Excretion in milk unknown; use with caution

Interactions

Side Effects

Side effects of Fenoldopam : Frequency Not Defined Angina Cardiac dysrhythmia Dizziness Flushing Heart failure Hypotension Myocardial infarction Tachycardia Headache Nausea Vomiting Serum creatinine raised

Mode of Action

D1-dopamine receptor agonist: rapid-acting vasodilator; decreases peripheral resistance and increases renal blood flow; has minimal adrenergic effects Also diuretic, natriuretic