Epalrestat

Indications

Epalrestat is used for: Diabetic neuropathy

Adult Dose

Oral Diabetic neuropathy Adult: 50 mg tid.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity. Pregnant or breastfeeding.

Precautions

Urine may turn yellowish brown or reddish after taking the medicine, because the yellowish brown or reddish color is attributed to components of this medicine.

Pregnancy-Lactation

Interactions

Side Effects

Side effects of Epalrestat : The most commonly reported adverse reactions include abdominal pain, nausea, rash, itch, erythema and blister.

Mode of Action

Epalrestat is aldose reductase inhibitor. The aldose reductase inhibitors have a distinct mechanism of action, affecting the underlying disease process in diabetic neuropathy, although the extent of the polyol pathway involvement is yet to be determined. Epalrestat reduces sorbitol accumulation in the sciatic nerve, erythrocytes. Epalrestat may improve motor and sensory nerve conduction velocity and subjective neuropathy symptoms.