Efalizumab

Indications

Efalizumab is used for: Psoriasis

Adult Dose

Subcutaneous Psoriasis Adult: Initially, 0.7 mg/kg; followed by a wkly dose of 1 mg/kg. Treatment period is usually 12 wk, to continue only when there is improvement. Max: 200 mg/dose.

Child Dose

Renal Dose

Administration

Contra Indications

Known hypersensitivity. Should not be used in patients with clinically important infections.

Precautions

Monitor platelet counts before and during treatment. Acellular, live and live-attenuated vaccines should not be given during treatment. Pregnancy and lactation.

Pregnancy-Lactation

Interactions

Avoid concurrent admin of other immunosuppressive agents or with phototherapy.

Side Effects

Side effects of Efalizumab : Headache, fever, nausea, vomiting.

Mode of Action

Efalizumab is a recombinant humanized anti-CD11a monoclonal antibody functioning as an immunosuppressive agent used in the management of moderate to severe chronic plaque psoriasis.