Calcium Citrate + Calcitriol

Indications

Calcium Citrate + Calcitriol is used for: Calcium and vitamin D3 supplement, Osteoporosis.

Adult Dose

Adult: PO: 1 tablet twice daily.

Child Dose

Renal Dose

Administration

Contra Indications

Patients with hypercalcaemia, hypercalciuria or hypophosphatemia. Nephrolithiasis, hypervitaminosis D.

Precautions

Impaired calcium absorption in achlorhydria which is common in elderly. Increased risk of hypercalcaemia and hypercalciuria in hypoparathyroid patients on high doses of vitamin D. History of kidney stones. Renal impairment.

Pregnancy-Lactation

Interactions

Reduced absorption of tetracyclines, quinolones and oral biphosphates with concurrent calcium use. Calcium absorption may be reduced by corticosteriods. Increased risk of hypercalcemia and metabolic alkalosis with thiazide diuretics. High blood calcium level may increase the effect of caridac glycosides. Reduced erlotinib efficacy with calcium. Increased risk of hypercalaemia with paricalcitol. Enzyme-inducing antiepileptics increases the metabolism of Vit D. Potentially Fatal: Fatal encephalopathy can occur in patients with renal failure when given calcium citrate and aluminium products concurrently due to marked rise in aluminium levelCalcium salt can be used in the prevention and treatment of calcium deficiency states or negative calcium balance. It is also used as an adjunct in the prevention and treatment of osteoporosis.

Side Effects

Side effects of Calcium Citrate + Calcitriol : Calcium Anorexia, Constipation, Flatulence, Nausea, Vomiting, Hypercalcemia, Hypophosphatemia, Xerostomia, Acid rebound, Milk-alkali syndrome, Coma, Confusion, Delirium, Headache, Lethargy. Calcitrol: Abdominal pain, Apathy, BUN and creatinine increased, Cardiac arrhythmia, Constipation, Dry mouth, Dehydration, Growth suppression, Headache, Hyperthermia, Hypercalcemia, Hypercholesteremia, Hypermagnesemia, Hyperphosphatemia, Hypertension, Libido decreased, Metallic taste, Muscle or bone pain, Nocturia, Pruritus, Psychosis, Somnolence, Weakness

Mode of Action

Calcitriol promotes calcium absorption in the intestines and retention at the kidneys thus increasing serum calcium levels. It also increases renal tubule phosphate resorption consequently decreasing serum phosphatase levels, PTH levels and bone resorption.