Calcipotriene 0.005%

Indications

Calcipotriene 0.005% is used for: Plaque psoriasis, Scalp psoriasis

Adult Dose

Apply a thin layer of ointment once or twice daily.

Child Dose

Renal Dose

Administration

Rub in gently and completely. May use for up to 8 weeks

Contra Indications

Patients with a history of hypersensitivity to any of the components of the preparation. It should not be used by patients with demonstrated hypercalcemia or evidence of vitamin D toxicity.

Precautions

For external use only. Keep out of the reach of children. Always wash hands thoroughly after use. Transient, rapidly reversible elevation of serum calcium has occurred with use . If elevation in serum calcium outside the normal range should occur, discontinue treatment until normal calcium levels are restored. Lactation: excretion in milk unknown; use with caution

Pregnancy-Lactation

Pregnancy No data available on drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes in pregnant women exposed to calcipotriene Foam: Systemic exposure to calcipotriene is likely to be low Animal data In animal reproduction studies, oral administration of calcipotriene to pregnant rats and rabbits during organogenesis resulted in an increased minor skeletal abnormalities, including enlarged fontanelles and extra ribs in rats and an increased incidence of minor skeletal abnormalities, including incomplete ossification of pubic bones and forelimb phalanges in rabbits Lactation There are no data on the presence of topically administered calcipotriene in human or animal milk, the effects on the breastfed infant, or the effects on milk production After topical administration, plasma concentrations of calcipotriene are low, and therefore, concentrations in human milk are likely to be low

Interactions

Side Effects

Side effects of Calcipotriene 0.005% : >10% Burning, Itching, Skin irritation 1-10% Dermatitis, Dry skin, Erythema, Peeling, Worsening of psoriasis including facial/scalp, Rash <1% Folliculitis, Hypercalcemia, Hyperpigmentation, Skin atrophy

Mode of Action

In vitro evidence suggests drug is roughly equipotent to natural vitamin D in its effects on proliferation & differentiation of various cell types.