Benzocaine + Oxytetracycline + Polymyxin B Eye prep
Indications
Benzocaine + Oxytetracycline + Polymyxin B Eye prep is used for:
Bacterial eye infections, Inflammation of the Cornea
Adult Dose
Opthalmic: 1-2 drops 2-4 times daily.
Child Dose
Renal Dose
Administration
Contra Indications
Known hypersensitivity to any of the components.
Precautions
Prolonged use. perforated ear drum.
Pregnancy-Lactation
Interactions
Side Effects
Side effects of Benzocaine + Oxytetracycline + Polymyxin B Eye prep :
Local sensitivity. Lid itching, swelling, conjunctival erythema.
Mode of Action
Benzocaine is a local anaesthetic which acts by preventing the generation and transmission of impulses along nerve fibers and at nerve endings. Depolarisation and ion-exchange are inhibited. In general, loss of pain occurs before loss of sensory, autonomic and motor functions.
Oxytetracycline binds reversibly to the 30S and possibly 50S ribosomal subunits, thus inhibiting bacterial protein synthesis and arresting cell growth. It is active against a wide range of gram-positive and gram-negative organisms.
Polymyxin B disrupts the bacterial cytoplasmic membrane of mostly gm-ve organisms allowing leakage of intracellular constituents by binding to membrane phospholipids.