Adapalene 0.1% Topical

Indications

Adapalene 0.1% Topical is used for: Acne, Keratosis pilaris

Adult Dose

Adult: Topical As 0.1% soln/cream/gel: Apply once daily at night after cleansing.

Child Dose

Renal Dose

Administration

Apply small (pea-sized) amount sparingly to entire face after cleansing with nonmedicated cleanser. For topical use only;

Contra Indications

Hypersensitivity.

Precautions

Patients with sunburn, eczema. Pregnancy, lactation. Avoid excessive exposure to sunlight or UV irradiation. Keep away from the eyes, lips, nostrils and mucous membranes. Do not apply to cuts, abrasions, scaly or flaky skin, or patches of sunburned skin. Use with caution with preparations containing sulfur, resorcinol, or salicylic acid. Lactation: Excretion in milk unknown; use with caution.

Pregnancy-Lactation

Pregnancy category: C Lactation: Excretion in milk unknown; use with caution

Interactions

Increased irritation may occur with medicated or abrasive soaps, products with a pronounced drying effect and those containing alcohol or astringents.

Side Effects

Side effects of Adapalene 0.1% Topical : >10% Dryness (1-45%), Scaling (1-44%), Burning/stinging (4-29%), Erythema (0.5-26%) 1-10% Skin discomfort (6%), Pruritus (2%), Desquamation (2%), Sunburn (1%) <1% Acne flare, Conjunctivitis, Contact dermatitis, Eczema, Erythema, Eyelid edema, Rash, Skin discoloration

Mode of Action

Adapalene binds to specific retinoic acid nuclear receptors which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.