Adapalene 0.1% Topical
Indications
Adapalene 0.1% Topical is used for:
Acne, Keratosis pilaris
Adult Dose
Adult: Topical As 0.1% soln/cream/gel: Apply once daily at night after cleansing.
Child Dose
Renal Dose
Administration
Apply small (pea-sized) amount sparingly to entire face after cleansing with nonmedicated cleanser.
For topical use only;
Contra Indications
Hypersensitivity.
Precautions
Patients with sunburn, eczema. Pregnancy, lactation. Avoid excessive exposure to sunlight or UV irradiation. Keep away from the eyes, lips, nostrils and mucous membranes. Do not apply to cuts, abrasions, scaly or flaky skin, or patches of sunburned skin. Use with caution with preparations containing sulfur, resorcinol, or salicylic acid.
Lactation: Excretion in milk unknown; use with caution.
Pregnancy-Lactation
Pregnancy category: C
Lactation: Excretion in milk unknown; use with caution
Interactions
Increased irritation may occur with medicated or abrasive soaps, products with a pronounced drying effect and those containing alcohol or astringents.
Side Effects
Side effects of Adapalene 0.1% Topical :
>10%
Dryness (1-45%), Scaling (1-44%), Burning/stinging (4-29%), Erythema (0.5-26%)
1-10%
Skin discomfort (6%), Pruritus (2%), Desquamation (2%), Sunburn (1%)
<1%
Acne flare, Conjunctivitis, Contact dermatitis, Eczema, Erythema, Eyelid edema, Rash, Skin discoloration
Mode of Action
Adapalene binds to specific retinoic acid nuclear receptors which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.