Acrivastine + Pseudoephedrine
Indications
Acrivastine + Pseudoephedrine is used for:
Seasonal Allergic Rhinitis, Nasal Congestion
Adult Dose
Seasonal Allergic Rhinitis or Nasal Congestion
8 mg/60 mg (1 capsule) PO q4-6h
>14 days continuous treatment efficacy not adequately investigated
Child Dose
Seasonal Allergic Rhinitis or Nasal Congestion
<12 years: Safety and efficacy not established
>12 years: 8 mg/60 mg (1 capsule) PO q4-6h
>14 days continuous treatment efficacy not adequately investigated
Renal Dose
Renal Impairment
CrCl>48mL/min: Dose adjustment not necessary
CrCl <48mL/min: Not recommended
Administration
Contra Indications
Hypersensitivity to acrivastine or other alkylamine antihistamines
Hypersensitivity to pseudoephedrine or other sympathomimetic amines
Severe hypertension
Severe coronary artery disease
Patients taking monoamine oxidase (MAO) inhibitors and for 14 days after stopping use of an MAO inhibitor
Precautions
Due to potential for sedation, assess individual responses before engaging in any activity requiring mental alertness, such as driving a motor vehicle or operating machinery
Concurrent use with alcohol or other CNS depressants may cause additional reductions in alertness and impairment of CNS performance and should be avoided
Not adequately studied for relieving common cold symptoms
Pregnancy-Lactation
Pregnancy Category: B
Lactation: Unknown whether acrivastine is distributed in breast milk, caution advised ; pseudoephedrine is excreted in human milk, caution advised
Interactions
Side Effects
Side effects of Acrivastine + Pseudoephedrine :
1-10%
Somnolence
Nervousness
Insomnia
Dry mouth
<1%
Headache
Dizziness
Asthenia
Nausea
Dyspepsia
Pharyngitis
Cough increase
Dysmenorrhea
Mode of Action
Acrivastine exhibits H1-antihistaminic receptor activity, which prevents histamine from binding to its receptor in target cells
Pseudoephedrine: Indirect sympathomimetic agent, releases norepinephrine from adrenergic nerves