Acalabrutinib

Indications

Acalabrutinib is used for: Mantle Cell Lymphoma

Adult Dose

Mantle Cell Lymphoma Indicated for mantle cell lymphoma (MCL) in adults who have received at least 1 prior therapy 100 mg PO q12hr

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Serious hemorrhagic events, including fatal events, reported; the mechanism for the bleeding events is not well understood; acalabrutinib may further increase hemorrhage risk in patients receiving antiplatelet or anticoagulant therapies, and patients should be monitored for signs of bleeding; consider the benefit-risk of withholding acalabrutinib for 3-7 days presurgery and postsurgery depending on the type of surgery and the risk of bleeding Serious infections (bacterial, viral, or fungal), including fatal events and opportunistic infections, reported; monitor for infection and consider prophylaxis in patients who are at increased risk for opportunistic infections Cytopenias reported, including neutropenia, anemia, and thrombocytopenia; assess complete blood cell counts monthly during treatment Second primary malignancies, including nonskin carcinomas, have occurred in patients with hematologic malignancies treated with acalabrutinib; the most frequent was skin cancer; advise patients regarding need for protection from sun exposure Atrial fibrillation and flutter occurred (rare) during clinical trials; monitor patients and manage as appropriate

Pregnancy-Lactation

Pregnancy Based on findings in animals, may cause fetal harm when administered to pregnant women There are no available data in pregnant women to inform the drug-associated risk In animal reproduction studies, administration of acalabrutinib to pregnant rabbits during organogenesis resulted in reduced fetal growth; rabbit maternal exposures (AUC) were ~4 times that of humans given a dose of 100 mg twice daily Advise pregnant women of the potential risk to a fetus Lactation No data are available regarding the presence of acalabrutinib or its active metabolite in human milk, its effects on the breastfed child, or on milk production Acalabrutinib and its active metabolite were present in the milk of lactating rats Owing to the potential for adverse reactions in a breastfed child, advise lactating women not to breastfeed while taking acalabrutinib and for at least 2 weeks after the final dose

Interactions

Coadministration with CYP3A inhibitors or inducers Acalabrutinib is predominantly metabolized by CYP3A enzymes CYP3A inhibitors are expected to increase acalabrutinib systemic exposure CYP3A inducers are expected to decrease acalabrutinib systemic exposure Coadministration with gastric acid-reducing agents Coadministration with PPIs, H2-antagonists, or antacids may decrease acalabrutinib plasma concentrations

Side Effects

Side effects of Acalabrutinib : >10% All grades Decreased hemoglobin (46%) Decreased platelets (44%) Headache (39%) Decreased neutrophils (36%) Diarrhea (31%) Fatigue (28%) Myalgia (21%) Bruising (21%) Nausea (19%) Rash (18%) Abdominal pain (15%) Constipation (15%) Vomiting (13%) Grade >3 Decreased neutrophils (15%) Decreased platelets (12%) 1-10% Increased creatinine, 1.5-3X ULN (4.8%) All grades Hemorrhage/hematoma (8%) Epistaxis (6%) Grade >3 Decreased hemoglobin (10%) Diarrhea (3.2%) Abdominal pain (1.6%) Headache (1.6%) Vomiting (1.6%)

Mode of Action

Bruton tyrosine kinase (BTK) inhibitor; acalabrutinib and its active metabolite, ACP-5862, form a covalent bond with a cysteine residue in the BTK active site, leading to inhibition of BTK enzymatic activity BTK is a signaling molecule of the B-cell antigen receptor (BCR) and cytokine receptor pathways; in B cells, BTK signaling results in activation of pathways necessary for B-cell proliferation, trafficking, chemotaxis, and adhesion