Abacavir + Dolutegravir + Lamivudine
Indications
Abacavir + Dolutegravir + Lamivudine is used for:
Human immunodeficiency virus type 1 (HIV-1) infection
Adult Dose
HIV Infection
Indicated for human immunodeficiency virus type 1 (HIV-1) infection in patients weighing >40 kg
1 tablet (600mg/50mg/300mg) PO qDay
Hepatic impairment
Mild: Not recommended; fixed-dose tablet cannot be dose adjusted
Moderate-to-severe: Contraindicated
Child Dose
HIV Infection
Indicated for human immunodeficiency virus type 1 (HIV-1) infection in patients weighing ?40 kg
<40 kg: Safety and efficacy not established
>40 kg: 1 tablet PO qDay
Renal Dose
Renal impairment
CrCl ?50 mL/min: No dosage adjustment required
CrCl <50 mL/min: Not recommended; fixed-dose tablet cannot be dose adjusted
Administration
Oral administration
Take with or without food
Contra Indications
Presence of HLA-B*5701 allele
Previous hypersensitivity reaction to abacavir, dolutegravir, or lamivudine
Coadministration with dofetilide
Moderate or severe hepatic impairment
Precautions
Use in patients with underlying hepatitis B or C may be associated with increased risk for worsening or development of elevated hepatic transaminase; monitor LFTs
Hepatic toxicity, including elevated serum liver biochemistries, hepatitis, and acute liver failure reported without pre-existing hepatic disease or other identifiable risk factors; drug-induced liver injury leading to liver transplant reported; monitoring for hepatotoxicity recommended
Hepatic decompensation, some fatal, has occurred in HIV-1/hepatitis C virus (HCV) coinfected patients receiving combination antiretroviral therapy (ART) and interferon alfa with or without ribavirin; discontinue as medically appropriate and consider dose reduction or discontinuation of interferon alfa, ribavirin, or both
Posttreatment exacerbation of hepatitis reported in patients coinfected with hepatitis B infection
Immune reconstitution syndrome may occur; patients may develop an inflammatory response to indolent or residual opportunistic infections (eg, Mycobacterium avium infection, cytomegalovirus infection, Pneumocystis jirovecii pneumonia [PCP] infection, or tuberculosis)
Administration is not recommended in patients receiving other products containing abacavir or lamivudine
Abacavir use was correlated with an increased risk of myocardial infarction (MI) based on a prospective, observational, epidemiological trial, but not in a meta-analysis of 26 randomized trials; caution with risks for coronary heart disease and minimizing modifiable risk factors, including smoking, hypertension, and hyperlipidemia
Pregnancy-Lactation
Pregnancy
Insufficient data related to abacavir/dolutegravir/lamivudine use during pregnancy to inform a drug associated risk of birth defects and miscarriage
In animal reproduction studies, no evidence of adverse developmental outcomes was observed with dolutegravir; during organogenesis in rat and rabbit and a rat pre/postnatal developmental study, systemic exposures (AUC) to dolutegravir were less than (rabbits) and ~50 times (rats) the exposure in humans at recommended human dose (RHD)
Oral administration of abacavir to pregnant rats during organogenesis resulted in fetal malformations and other embryonic and fetal toxicities at exposures 35 times the human exposure (AUC) at the RHD; no adverse developmental effects were observed following oral administration of abacavir to pregnant rabbits during organogenesis at exposures ~9 times the human exposure (AUC) at the RHD
Oral administration of lamivudine to pregnant rabbits during organogenesis resulted in embryo lethality at a human exposure (AUC) similar to the RHD; no adverse development effects were observed with oral administration of lamivudine to pregnant rats during organogenesis at plasma concentrations (Cmax) 35 times RHD
Potential risk of neural tube birth defects
Serious cases of neural tube birth defects involving the brain, spine, and spinal cord reported in babies born to women treated with dolutegravir
Preliminary results from an ongoing observational study in Botswana found women who had received dolutegravir at the time of becoming pregnant or early in the first trimester appear to be at higher risk for these defects; to date, in this observational study there are no reported cases of babies born with neural tube defects to women starting dolutegravir later in pregnancy
Recommendations
Patients should not discontinue dolutegravir without consulting a healthcare professional because stopping your medicine can cause the HIV infection to worsen
Pregnant women stopping dolutegravir-containing regimen without switching to alternative HIV medicines could cause the amount of virus to increase and spread HIV to your baby
Patients taking a dolutegravir-containing regimen at the time of becoming pregnant and during the first trimester of pregnancy, there is a potential risk of neural tube defects; neural tube defects happen early in pregnancy, before many women even know they are pregnant
Inform women of childbearing age about the potential risk of neural tube defects when a dolutegravir-containing regimen is used at the time of conception and early in pregnancy; women of childbearing age should consult their healthcare providers about other non-dolutegravir-containing antiretroviral medicine
Healthcare providers should weigh the benefits and the risks of dolutegravir when prescribing antiretroviral medicines to women of childbearing age; consider alternative antiretroviral medicines; discuss the relative risks and benefits of appropriate alternative antiretroviral therapies
Women of childbearing age who decide to take a dolutegravir-containing regimen should consistently use effective birth control (contraception) while on HIV treatment; women should discuss their healthcare professionals about an effective birth control method to use while taking a dolutegravir-containing regimen
Perform pregnancy testing before initiating a dolutegravir-containing regimen in women of childbearing age to exclude pregnancy
Lactation
The Centers for Disease Control and Prevention does not recommend HIV-1-infected mothers in the United States breastfeed their infants to avoid the risk of postnatal transmission of HIV-1 infection
Abacavir and lamivudine are present in human milk
When administered to lactating rats, dolutegravir was present in milk
There is no information on the effects of abacavir/dolutegravir/lamivudine or its components on the breastfed infant or the effects of the drug on milk production; because of the potential for HIV-1 transmission in HIV-negative infants, developing viral resistance (in HIV-positive infants), and serious adverse reactions in a breastfed infant, instruct mothers not to breastfeed
Interactions
Side Effects
Side effects of Abacavir + Dolutegravir + Lamivudine :
1-10%
Lipase (4-9%)
Hyperglycemia (2-7%)
Creatinine kinase (4-5%)
Insomnia (3%)
Decreased neutrophils (2-3%)
Increased AST (<1 to 3%)
Headache (2%)
Fatigue (2%)
Increased ALT (<1 to 2%)
Depression (1%)
<1%
Abnormal dreams
Dizziness
Nausea
Diarrhea
Rash
Mode of Action
Abacavir: Nucleoside reverse transcriptase inhibitor (NRTI); guanosine analog that inhibits HIV-1 reverse transcriptase by competing with dGTP as substrate, which, in turn, inhibits viral replication
Dolutegravir: Integrase strand transfer inhibitor (INSTI); inhibits catalytic activity of HIV-1 integrase, an HIV encoded enzyme required for viral replication
Lamivudine: NRTI; following phosphorylation, inhibits HIV reverse transcriptase by viral DNA chain termination; cytosine analog