Indications
Vextra Tablet is used for:
Osteoarthritis, Rheumatoid arthritis, Dysmenorrhoea
Adult Dose
Oral
Osteoarthritis, Rheumatoid arthritis
Adult: 10 mg once daily.
Dysmenorrhoea
Adult: 20 mg bid.
Hepatic Impairment
Child-Pugh scale 7-9: Initiate with caution. Child-Pugh scale >10: Avoid.
Child Dose
Renal Dose
Renal Impairment
CrCl Dosage
<30 Initiate with caution.
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity to sulfonamides, NSAIDs and other COX 2 inhibitors; asthma, urticaria; severe hepatic impairment; pregnancy (third trimester); lactation. Active GI bleed or ulceration, severe CHF, inflammatory bowel disease.
Precautions
Mild to moderate hepatic impairment; history of ulcer disease or GI bleeding; dehydration, hypertension, history of heart failure, left ventricular dysfunction, pre-existing oedema. Monitor Hb or haematocrit values for signs and symptoms of anaemia.
Pregnancy-Lactation
Interactions
Concomitant admin of aspirin may result in an increased risk of GI ulceration and complications. It decreases the antihypertensive effect of antihypertensives e.g. ACE inhibitors. It increases plasma conc of dextromethorphan. It significantly decreases lithium serum clearance and renal clearance.
Side Effects
Side effects of Valdecoxib :
Hypertension, back pain, myalgia, peripheral oedema, influenza-like symptoms, dizziness, headache, abdominal fullness, abdominal pain, diarrhoea, dyspepsia, flatulence, nausea, myalgia, sinusitis.
Potentially Fatal: Toxic epidermal necrolysis, exfoliative dermatitis.
Mode of Action
Valdecoxib acts by selectively inhibiting prostaglandin synthesis primarily by blocking cyclooxygenase (COX-2) enzyme. It was withdrawn worldwide, following risk of serious skin reactions and cardiovascular side effects.
Note
Vextra 20mg Tablet generic name is Valdecoxib. Vextra 20mg Tablet is manufactured by Orion Pharma Ltd.Vextra is availble in all over Bangladesh.
Mes BD drug index information on Vextra Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.