Venopex Injection
Iron (III)-Hydroxide Dextran Complex
100 mg/5 ml
Apex Pharma Limited.
| Pack size | |
|---|---|
| Unite Price | 325.00 BDT |
Indications
Venopex Injection is used for:
Iron deficiency anaemia
Adult Dose
Parenteral
Iron-deficiency anaemia
Adult: 25-100 mg IV or deep IM qDay PRN
Not to exceed 100 mg (2 mL)/day
Total dose (ml) = 0.0442 (desired haemoglobin - observed haemoglobin) x LBW + (0.26 x LBW) (Note: LBW = Lean body weight(kg))
Blood loss: total iron dose in mg = blood loss (mL) x HCT
A test dose of 0.5 ml should be given and observe patient for at least 1 hr for signs for hypersensitivity.
Total dose may be given in divided doses on a daily or twice wkly basis via IM inj (into the upper outer quadrant of the buttock); may also be given intravenously by total-dose infusion or as divided inj.
Child Dose
Iron-deficiency Anemia
5-15 kg
Not to be given in first 4 months of life
Dose = 0.0442(Desired Hgb - Observed Hgb) x BW(kg) + (0.26 × BW)
Desired hemoglobin usually 12 g/dL
>15 kg: 0.0442(Desired Hgb - Observed Hgb) x Lean BW(kg) + (0.26 × Lean BW)
Renal Dose
Administration
IV Preparation
Standard diluent: dose/250-1000 mL NS
Minimum volume: 250 mL NS
IV/IM Administration
IM: use z-track technique for IM administration (deep into upper outer quadrant of buttock)
IV may be administered bolus at <50 mg/min or diluted in 250-1000 mL NS & infused over 1-6 hr
Infuse initial 25 mL slowly, observe for allergic reactions
Contra Indications
Known serious hypersensitivity to other parenteral iron products.
Non-iron deficiency anaemia (e.g. haemolytic anaemia).
Iron overload or disturbances in utilisation of iron (e.g. haemochromatosis, haemosiderosis).
Decompensated liver cirrhosis and hepatitis.
Acute or chronic infection, because parenteral iron administration may exacerbate bacterial or viral infections.
Acute renal failure.
Precautions
Parenterally administered iron preparations can cause hypersensitivity reactions including serious and potentially fatal anaphylactic/anaphylactoid reactions. Hypersensitivity reactions have also been reported after previously uneventful doses of parenteral iron complexes.
The risk is enhanced for patients with known allergies including drug allergies, including patients with a history of severe asthma, eczema or other atopic allergy.
Hypotensive episodes may occur if intravenous injection is administered too rapidly.
Lactation: traces excreted in breast milk, use caution
Pregnancy-Lactation
Pregnancy Category: C
Lactation: traces excreted in breast milk, use caution
Interactions
Reduced Fe absorption upon oral Fe administration earlier than 5 days after the last inj. Reduced effect when used with chloramphenicol.
Side Effects
Side effects of Iron (III)-Hydroxide Dextran Complex :
1-10%
Abdominal pain, Diarrhea, Nausea, Vomiting, Arthralgia, Arthritis, Soreness, Inflammation, Pruritus, Rash, Urticaria, Brown discoloration of skin
Frequency Not Defined
Seizure, Chest pain, Hypotensive shock, Dyspnea, Respiratory arrest, Leukocytosis, Anaphylaxis, Hematuria
Mode of Action
Iron dextran is used for the treatment of iron-deficiency anaemia where oral therapy is ineffective or impracticable. Released iron replaces the depleted iron stores in the bone marrow where it is used in the synthesis of haemoglobin.
Note
Venopex 100 mg/5 ml Injection generic name is Iron (III)-Hydroxide Dextran Complex. Venopex 100 mg/5 ml Injection is manufactured by Apex Pharma Limited.Venopex is availble in all over Bangladesh.
Mes BD drug index information on Venopex Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.