Vaspine Injection

Bupivacaine + Dextrose

20mg + 320mg/4 ml

Healthcare Pharmaceuticals Ltd.

Pack size
Unite Price	32.00 BDT

Indications

Vaspine Injection is used for: Intrathecal anesthesia, Spinal anesthesia, Epidural anesthesia, Subarachnoid anesthesia

Adult Dose

Adult: Inj Percutaneous infiltration anesth For prolonged action: 9 mg w/ adrenaline (1 in 200,000), may repeat 2-10 mins later if needed. Max: 90 mg per dental sitting. Surgical anaesthesia Peripheral nerve block 12.5 mg (as 0.25% soln) or 25 mg (as 0.5% soln) . Max: 150 mg/dose. Sympathetic nerve block As 0.25% soln: 50-125 mg. Retrobulbar block As 0.75% soln: 15-30 mg. Caudal block In surgery: 37.5-75 mg (as 0.25% soln) or 75-150 mg (as 0.5% soln). Lumbar epidural block In surgery: 25-50 mg (as 0.25% soln) and 50-100 mg (as 0.5% soln). Spinal block: 0.5% soln: 10-20 mg (2-4 mL).

Child Dose

<12 years: Not recommended Caudal Block, Epidural Block, Local Block >12 years Local Anesthesia: Infiltration 0.25% infiltrated locally: 175 mg maximum Caudal Block: 15-30 mL of 0.25% or 0.5% (preservative free) Epidural Block Other Than Caudal Block: 10-20 mL of 0.25% or 0.5%; administer in 3-5 mL increments allowing sufficient time to detect toxic manifestations of inadvertent IV or IT administration (preservative free); for surgical procedures requiring high degree of muscle relaxation and prolonged effects administer10-20 mL of 0.75%; not to be used in obstetrical cases Peripheral or Sympathetic Nerve Block >12 years Peripheral Nerve Block: 5 mL of 0.25-0.5%; 400 mg/day maximum Sympathetic Nerve Block: 20-50 mL of 0.25%

Renal Dose

Administration

Contra Indications

Hypersensitivity to local anaesthetics of amide type. IV regional anaesthesia; paracervical block in obstetrics; spinal anaesthesia <18 yr. Lactation. Solutions containing preservatives for caudal or epidural block.

Precautions

Hepatic disease; CV disease; children <12 yr; pregnancy. Elderly and debilitated patients. Lactation: excretion in milk unknown/not recommended

Pregnancy-Lactation

Pregnancy Category: C Lactation: excretion in milk unknown/not recommended

Interactions

Additive systemic toxic effect w/ other local anaesth or agents structurally related to amide-type local anaesth (e.g. lidocaine and mexiletine). Increased risk of myocardial depression w/ antiarrhythmics. Enhanced adverse effects w/ hyaluronidase. Decreased clearance resulting to increased plasma concentrations w/ cimetidine and ranitidine. Increased risk of adverse effects w/ beta-blockers and Ca channel blockers.

Side Effects

Side effects of Bupivacaine + Dextrose : CNS excitation may be followed by depression. Hypotension, bradycardia, arrhythmias and cardiac arrest; methaemoglobinaemia; seizures, restlessness, dizziness. Hypersensitivity. Prolonged block, Edema, Headache, Hypotension, Hypoventilation, Nausea, Nervousness, Palpitation, Respiratory arrest, Tachycardia, Tinnitus, Tremors, Vomiting. Potentially Fatal: Cardiac and sudden respiratory arrest.

Mode of Action

Bupivacaine blocks both the initiation and conduction of nerve impulses reducing the permeability of neuronal membranes to Na ions resulting in inhibition of depolarization w/ resultant blockade of conduction. Dextrose is a monosaccharide that is used as a source of calories and water for hydration. It helps to reduce loss of body protein and nitrogen. It also promotes glycogen deposition in the liver.

Note

Vaspine 20mg + 320mg/4 ml Injection generic name is Bupivacaine + Dextrose. Vaspine 20mg + 320mg/4 ml Injection is manufactured by Healthcare Pharmaceuticals Ltd.Vaspine is availble in all over Bangladesh. Mes BD drug index information on Vaspine Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Bupivacaine + Dextrose :

Injection

Bupicaine Heavy ^0.5%+8%

Chemist Laboratories Ltd.

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Duracain ^{20mg + 320mg}

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Injection

Sivicaine Heavy ^{20 mg + 320 mg/4 ml}

Renata Limited

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Ultracaine Heavy ^{20 mg + 320 mg/4 ml}

Jayson Pharmaceuticals Ltd.

Injection

G-Bupivacaine Heavy ^4ml

Gonoshasthaya Pharmaceuticals Ltd.