Utifos Oral Powder
Fosfomycin
3 gm/sachet
Radiant Pharmaceutical Ltd.
| Pack size | 3 gm |
|---|---|
| Unite Price | 350.00 BDT |
Indications
Utifos Oral Powder is used for:
Uncomplicated urinary tract infections (acute cystitis), Prostatitis
Adult Dose
Oral
Urinary Tract Infection (Acute Cystitis)
Acute cystitis caused by E. coli, E. faecalis
Women >18 years: 1 sachet (3 g) PO once
Males >18 years: 1 sachet (3 g) every 2-3 days for 3 doses
Prostatitis
3 g PO every 3 days for 21 days
Child Dose
Renal Dose
Renal impairment: No dosage adjustment needed.
Administration
Reconstitution: Oral powd: Dissolve the contents of a single-dose sachet containing 3 g of the drug in 90-120 ml (half cup) of water of water and stir to dissolve. Do not use hot water. This should be taken immediately after dissolving in water. Do not use hot water.
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Contra Indications
Hypersensitivity to fosfomycin.
Precautions
Patient w/ cardiac insufficiency, HTN, hyperaldosteronism, hypernatraemia or pulmonary oedema. Renal impairment (IV). Pregnancy and lactation.
Patient Counseling Certain adverse effects may occur which may impair ability to drive or operate machinery. Monitoring Parameters Monitor serum electrolyte levels and water balance; signs and symptoms of UTI. Do not use more than one single dose to treat a single episode of acute cystitis. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic.
Lactation: excreted in breast milk; not recommended
Pregnancy-Lactation
Pregnancy Category: B
Lactation: excreted in breast milk; not recommended
Interactions
Additive or synergistic effect w/ β-lactam antibiotics (e.g. penicillin, ampicillin, cefazolin, carbapenems) and anti-staphylococcal agents (e.g. linezolid, quinupristin/dalfopristin, moxifloxacin). Reduced serum levels w/ drugs which increase GI motility (e.g. metoclopramide).
Side Effects
Side effects of Fosfomycin :
1-10%
Anorexia, Diarrhea, Epigastric, Discomfort, Headache, Nausea, Rash, Vomiting
<1%
Dizziness, Drowsiness, Fatigue, Pruritus
Potentially Fatal: Anaphylactic shock, antibiotic-associated colitis and pseudomembranous colitis.
Mode of Action
Fosfomycin is a phosphoenolpyruvate (PEP) analogue that irreversibly inhibits enolpyruvate transferase (MurA), which prevents peptidoglycan biosynthesis at an earlier site compared to β-lactams with no cross-resistance with other agents. Thus, it inhibits bacterial cell wall biogenesis & shows bactericidal effects.
Note
Utifos 3 gm/sachet Oral Powder generic name is Fosfomycin. Utifos 3 gm/sachet Oral Powder is manufactured by Radiant Pharmaceutical Ltd.Utifos is availble in all over Bangladesh.
Mes BD drug index information on Utifos Oral Powder is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.