Uroflo Plus Capsule

Tamsulosin + Dutasteride

400mcg + 500mcg

Beximco Pharmaceuticals Ltd.

Pack size
Unite Price	20.00 BDT

Indications

Uroflo Plus Capsule is used for: Benign prostatic hyperplasia

Adult Dose

Oral Benign prostatic hyperplasia Adult: 1 cap once daily.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity, severe liver impairment. Pregnancy, lactation, child, adolescent.

Precautions

Excreted in semen therefore use of condom is recommended. Women of childbearing potential should avoid handling leaking capsules of dutasteride. Prostate carcinoma should be ruled out before starting the therapy. Blood donation to be avoided during and at least 6 mths after discontinuance of drug.

Pregnancy-Lactation

Pregnancy Category: X Lactation: Unknown whether distributed in breast milk, contraindicated in breastfeeding women

Interactions

Concomitant admin with moderate or strong inhibitors of CYP2D6 (eg. fluoxetine) or CYP34A (eg. ketoconazole, cimetidine) increases tamsulosin serum concentration; increase in blood concentrations of dutasteride in the presence of inhibitors of CYP3A4/5 such as ritonavir, ketoconazole, verapamil, diltiazem, cimetidine, troleandomycin, and ciprofloxacin.

Side Effects

Side effects of Tamsulosin + Dutasteride : >10% Orthostasis (16%) 1-10% Ejaculation disorders (10%), Dizziness (2%), Breast enlargement/tenderness (3%), Impotence (8%), Decreased libido (4.5%), Breast disorders (1%) <1% Prostate cancer (high grade)

Mode of Action

Tamsulosin is a selective alpha-1 adrenoceptor blocker. It blocks alpha-1 adrenoceptors, which are abundant in the prostate, prostatic capsule, prostatic urethra, and bladder neck, resulting relaxation of these adrenoceptors in the bladder neck and prostate. Thus, there is an improvement in urine flow rate and reduction in symptoms of benign prostatic hypertrophy (BPH). Dutasteride inhibits 5 alpha-reductase, the enzyme responsible for conversion of testosterone to 5 alpha-dihydrotestosterone (DHT). DHT appears to be the principal androgen responsible for stimulation of prostatic growth.

Note

Uroflo Plus 400mcg + 500mcg Capsule generic name is Tamsulosin + Dutasteride. Uroflo Plus 400mcg + 500mcg Capsule is manufactured by Beximco Pharmaceuticals Ltd.Uroflo Plus is availble in all over Bangladesh. Mes BD drug index information on Uroflo Plus Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Tamsulosin + Dutasteride :

Capsule

Uromax D ^{400 mcg+500 mcg}

Unimed & Unihealth Manufacturers Ltd.

Capsule

Combomax ^{400 mcg + 500 mcg}

Drug International Ltd.

Capsule

Tamsin D ^{400mcg + 500mcg}

Delta Pharma Limited

Capsule

Uropass-D ^{0.4mg + 0.5mg}

Acme Laboratories Ltd.

Capsule

Urolosin D ^{500 mcg + 400 mcg}

General Pharmaceuticals Ltd.